Four weeks toxicity study of 4-methoxytoluene in rats

B. Brunsborg; Otto A. Meyer; G. Würtzen; P. Olsen

doi:10.1016/0378-4274(94)90060-4

Four weeks toxicity study of 4-methoxytoluene in rats

B. Brunsborg, Otto A. Meyer, G. Würtzen, P. Olsen

National Food Institute

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Abstract

4-Methoxytoluene was given by gavage to 4 groups of 20 rats at dosage levels of 0, 40, 120 or 240 mg kg^-1 body weight/day for 4 weeks. There was a statistically significant decrease in serum creatinine and urea in the intermediate and high dose group for both sexes. Among males, a statistically significant decrease in the packed cell volume was observed in the high and intermediate dose group. A no-observed-effect level of 40 mg kg^-1 body weight/day was determined.

Original language	English
Journal	Toxicology Letters
Volume	73
Issue number	3
Pages (from-to)	209-212
ISSN	0378-4274
DOIs	https://doi.org/10.1016/0378-4274(94)90060-4
Publication status	Published - 1994

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title = "Four weeks toxicity study of 4-methoxytoluene in rats",

abstract = "4-Methoxytoluene was given by gavage to 4 groups of 20 rats at dosage levels of 0, 40, 120 or 240 mg kg-1 body weight/day for 4 weeks. There was a statistically significant decrease in serum creatinine and urea in the intermediate and high dose group for both sexes. Among males, a statistically significant decrease in the packed cell volume was observed in the high and intermediate dose group. A no-observed-effect level of 40 mg kg-1 body weight/day was determined.",

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AU - Brunsborg, B.

AU - Meyer, Otto A.

AU - Würtzen, G.

AU - Olsen, P.

PY - 1994

Y1 - 1994

N2 - 4-Methoxytoluene was given by gavage to 4 groups of 20 rats at dosage levels of 0, 40, 120 or 240 mg kg-1 body weight/day for 4 weeks. There was a statistically significant decrease in serum creatinine and urea in the intermediate and high dose group for both sexes. Among males, a statistically significant decrease in the packed cell volume was observed in the high and intermediate dose group. A no-observed-effect level of 40 mg kg-1 body weight/day was determined.

AB - 4-Methoxytoluene was given by gavage to 4 groups of 20 rats at dosage levels of 0, 40, 120 or 240 mg kg-1 body weight/day for 4 weeks. There was a statistically significant decrease in serum creatinine and urea in the intermediate and high dose group for both sexes. Among males, a statistically significant decrease in the packed cell volume was observed in the high and intermediate dose group. A no-observed-effect level of 40 mg kg-1 body weight/day was determined.

U2 - 10.1016/0378-4274(94)90060-4

DO - 10.1016/0378-4274(94)90060-4

M3 - Journal article

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VL - 73

SP - 209

EP - 212

JO - Toxicology Letters

JF - Toxicology Letters

IS - 3

ER -

Four weeks toxicity study of 4-methoxytoluene in rats

Abstract

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