Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana

Henrik Toft Simonsen

doi:10.1016/j.phytol.2012.03.005

Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana

Henrik Toft Simonsen

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Four novel geminally dialkylated, non-aromatic acetophenone derivatives 1-4 were isolated from Melicope coodeana. The compounds, related to hop bitter acids, were named Coodeanones A-C, where Coodeanone B was found in both E and Z configuration of the 6 ''''-7 '''' double bond. Antibacterial, antifungal and antimalarial activities of the acetophenone derivaties were investigated, and Coodeanone C (4) was found to have activity toward Plasmodium falciparum (malaria) (IC₅₀ = 42.8 μM).

Original language	English
Journal	Phytochemistry Letters
Volume	5
Issue number	2
Pages (from-to)	371-375
Number of pages	5
ISSN	1874-3900
DOIs	https://doi.org/10.1016/j.phytol.2012.03.005
Publication status	Published - 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Non-aromatic acetophenone
Melicope
Rutaceae

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10.1016/j.phytol.2012.03.005

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title = "Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana",

abstract = "Four novel geminally dialkylated, non-aromatic acetophenone derivatives 1-4 were isolated from Melicope coodeana. The compounds, related to hop bitter acids, were named Coodeanones A-C, where Coodeanone B was found in both E and Z configuration of the 6 ''''-7 '''' double bond. Antibacterial, antifungal and antimalarial activities of the acetophenone derivaties were investigated, and Coodeanone C (4) was found to have activity toward Plasmodium falciparum (malaria) (IC50 = 42.8 μM).",

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T1 - Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana

AU - Simonsen, Henrik Toft

PY - 2012

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N2 - Four novel geminally dialkylated, non-aromatic acetophenone derivatives 1-4 were isolated from Melicope coodeana. The compounds, related to hop bitter acids, were named Coodeanones A-C, where Coodeanone B was found in both E and Z configuration of the 6 ''''-7 '''' double bond. Antibacterial, antifungal and antimalarial activities of the acetophenone derivaties were investigated, and Coodeanone C (4) was found to have activity toward Plasmodium falciparum (malaria) (IC50 = 42.8 μM).

AB - Four novel geminally dialkylated, non-aromatic acetophenone derivatives 1-4 were isolated from Melicope coodeana. The compounds, related to hop bitter acids, were named Coodeanones A-C, where Coodeanone B was found in both E and Z configuration of the 6 ''''-7 '''' double bond. Antibacterial, antifungal and antimalarial activities of the acetophenone derivaties were investigated, and Coodeanone C (4) was found to have activity toward Plasmodium falciparum (malaria) (IC50 = 42.8 μM).

KW - Non-aromatic acetophenone

KW - Melicope

KW - Rutaceae

U2 - 10.1016/j.phytol.2012.03.005

DO - 10.1016/j.phytol.2012.03.005

M3 - Journal article

SN - 1874-3900

VL - 5

SP - 371

EP - 375

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 2

ER -

Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana

Abstract

UN SDGs

Keywords

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