Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana

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Abstract

Four novel geminally dialkylated, non-aromatic acetophenone derivatives 1-4 were isolated from Melicope coodeana. The compounds, related to hop bitter acids, were named Coodeanones A-C, where Coodeanone B was found in both E and Z configuration of the 6 ''''-7 '''' double bond. Antibacterial, antifungal and antimalarial activities of the acetophenone derivaties were investigated, and Coodeanone C (4) was found to have activity toward Plasmodium falciparum (malaria) (IC50 = 42.8 μM).
Original languageEnglish
JournalPhytochemistry Letters
Volume5
Issue number2
Pages (from-to)371-375
Number of pages5
ISSN1874-3900
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Non-aromatic acetophenone
  • Melicope
  • Rutaceae

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