Abstract
The chemical activity of an organic chemical quantifies its potential for spontaneous physicochemical processes, such as diffusion, sorption, and partitioning. For instance, the chemical activity of a sediment contaminant determines its equilibrium partitioning concentration in sediment-dwelling organisms and differences in chemical activity determine the direction and extent of diffusion between environmental compartments [1,2]. This makes chemical activity a meaningfull and well-defined exposure parameter that is closely linked to fugacity and freely dissolved concentration [2]. Classical toxicological studies have provided the first indication that narcosis occurs within a relatively narrow band of chemical activity [3-5], and during the last 10 years several studies have confirmed this for the „baseline toxicity“ of non-polar organic chemicals and their mixtures [6-8].
The first aim of this presentation will be to emphasize the physical meaning of chemical activity, basically suggesting that „mass concentration“ and „chemical activity“ are two complemtary dimensions for chemicals in the environment, exactly like we know from other areas (heat content versus temperature; water content versus water activity). The second aim will be to present how chemical activity can be measured and controlled in environmental research and testing, since this has the very important implication that chemical activity goes beyond modelling and re-calculations of mass based data. The final aim will be to initiate the discussion of why and how „chemical activity“ can help (1) to link exposure between media, (2) to compare sensitivities between species, (3) to assess (excess) toxicity of chemicals and (4) to add up the exposure for mixtures?
The first aim of this presentation will be to emphasize the physical meaning of chemical activity, basically suggesting that „mass concentration“ and „chemical activity“ are two complemtary dimensions for chemicals in the environment, exactly like we know from other areas (heat content versus temperature; water content versus water activity). The second aim will be to present how chemical activity can be measured and controlled in environmental research and testing, since this has the very important implication that chemical activity goes beyond modelling and re-calculations of mass based data. The final aim will be to initiate the discussion of why and how „chemical activity“ can help (1) to link exposure between media, (2) to compare sensitivities between species, (3) to assess (excess) toxicity of chemicals and (4) to add up the exposure for mixtures?
Original language | English |
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Title of host publication | ECETOC: Defining the role of chemical activity in environmental risk assessment within the context of mode of action: Practical guidance and advice : Workshop programme |
Place of Publication | Utah, USA |
Publication date | 2015 |
Pages | 14-14 |
Publication status | Published - 2015 |
Event | ECETOC 2015:: Defining the role of chemical activity in environmental risk assessment within the context of mode of action: Practical guidance and advice - Snowbird Resort, Snowbird, United States Duration: 29 Oct 2015 → 30 Oct 2015 |
Conference
Conference | ECETOC 2015: |
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Location | Snowbird Resort |
Country/Territory | United States |
City | Snowbird |
Period | 29/10/2015 → 30/10/2015 |