Formulation of api's and excipient's in an icell via hydrophobic ion pairing

Thomas Lars Andresen; Jonas Rosager Henriksen; Anders Elias Hansen; Albert Juan Fuglsang-Madsen; Elizabeth Serrano Chávez; Unnur Jóna Björgvinsdóttir; Xin Li

Formulation of api's and excipient's in an icell via hydrophobic ion pairing

Thomas Lars Andresen (Inventor)
, Jonas Rosager Henriksen (Inventor)
, Anders Elias Hansen (Inventor)
, Albert Juan Fuglsang-Madsen (Inventor)
, Elizabeth Serrano Chávez (Inventor)
, Unnur Jóna Björgvinsdóttir (Inventor)
, Xin Li (Inventor)

Research output: Patent

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Abstract

The present invention refers to a composition forming a hydrophobic ion par (HIP), comprising: a. an imaging agent and/or a pharmaceutical agent with zwitterionic, cationic or anionic charge; b. a counterion being a hydrophobic or amphiphilic acid or base, or salt thereof; c. a non-water soluble carbohydrate; d. a non-aqueous solvent; wherein at least 30% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of disaccharides or trisaccharides, or mixtures thereof; wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 10,000 centipoise (cP) after administration to transform into an ICell; and wherein the hydrophobic or amphiphilic acid or base or salt thereof modulates the solubility of the imaging agent and/or the pharmaceutical agent in the ICell by forming a hydrophobic ion-pair or multiple hydrophobic ion-pairs with the imaging agent and/or the pharmaceutical agent.

Original language	English
IPC	A61P 35/ 00 A I
Patent number	WO2023227517
Filing date	23/05/2022
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	23/05/2022
Priority number	EP20220174814
Publication status	Published - 30 Nov 2023

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title = "Formulation of api's and excipient's in an icell via hydrophobic ion pairing",

abstract = "The present invention refers to a composition forming a hydrophobic ion par (HIP), comprising: a. an imaging agent and/or a pharmaceutical agent with zwitterionic, cationic or anionic charge; b. a counterion being a hydrophobic or amphiphilic acid or base, or salt thereof; c. a non-water soluble carbohydrate; d. a non-aqueous solvent; wherein at least 30\% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of disaccharides or trisaccharides, or mixtures thereof; wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 10,000 centipoise (cP) after administration to transform into an ICell; and wherein the hydrophobic or amphiphilic acid or base or salt thereof modulates the solubility of the imaging agent and/or the pharmaceutical agent in the ICell by forming a hydrophobic ion-pair or multiple hydrophobic ion-pairs with the imaging agent and/or the pharmaceutical agent.",

author = "Andresen, \{Thomas Lars\} and Henriksen, \{Jonas Rosager\} and Hansen, \{Anders Elias\} and Fuglsang-Madsen, \{Albert Juan\} and \{Serrano Ch{\'a}vez\}, Elizabeth and Bj{\"o}rgvinsd{\'o}ttir, \{Unnur J{\'o}na\} and Xin Li",

year = "2023",

month = nov,

day = "30",

language = "English",

type = "Patent",

note = "WO2023227517; A61P 35/ 00 A I",

}

TY - PAT

T1 - Formulation of api's and excipient's in an icell via hydrophobic ion pairing

AU - Andresen, Thomas Lars

AU - Henriksen, Jonas Rosager

AU - Hansen, Anders Elias

AU - Fuglsang-Madsen, Albert Juan

AU - Serrano Chávez, Elizabeth

AU - Björgvinsdóttir, Unnur Jóna

AU - Li, Xin

PY - 2023/11/30

Y1 - 2023/11/30

N2 - The present invention refers to a composition forming a hydrophobic ion par (HIP), comprising: a. an imaging agent and/or a pharmaceutical agent with zwitterionic, cationic or anionic charge; b. a counterion being a hydrophobic or amphiphilic acid or base, or salt thereof; c. a non-water soluble carbohydrate; d. a non-aqueous solvent; wherein at least 30% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of disaccharides or trisaccharides, or mixtures thereof; wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 10,000 centipoise (cP) after administration to transform into an ICell; and wherein the hydrophobic or amphiphilic acid or base or salt thereof modulates the solubility of the imaging agent and/or the pharmaceutical agent in the ICell by forming a hydrophobic ion-pair or multiple hydrophobic ion-pairs with the imaging agent and/or the pharmaceutical agent.

AB - The present invention refers to a composition forming a hydrophobic ion par (HIP), comprising: a. an imaging agent and/or a pharmaceutical agent with zwitterionic, cationic or anionic charge; b. a counterion being a hydrophobic or amphiphilic acid or base, or salt thereof; c. a non-water soluble carbohydrate; d. a non-aqueous solvent; wherein at least 30% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of disaccharides or trisaccharides, or mixtures thereof; wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 10,000 centipoise (cP) after administration to transform into an ICell; and wherein the hydrophobic or amphiphilic acid or base or salt thereof modulates the solubility of the imaging agent and/or the pharmaceutical agent in the ICell by forming a hydrophobic ion-pair or multiple hydrophobic ion-pairs with the imaging agent and/or the pharmaceutical agent.

M3 - Patent

M1 - WO2023227517

Y2 - 2022/05/23

ER -

Formulation of api's and excipient's in an icell via hydrophobic ion pairing

Abstract

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