Abstract
The present invention refers to a composition forming a hydrophobic ion par (HIP), comprising: a. an imaging agent and/or a pharmaceutical agent with zwitterionic, cationic or anionic charge; b. a counterion being a hydrophobic or amphiphilic acid or base, or salt thereof; c. a non-water soluble carbohydrate; d. a non-aqueous solvent; wherein at least 30% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of disaccharides or trisaccharides, or mixtures thereof; wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 10,000 centipoise (cP) after administration to transform into an ICell; and wherein the hydrophobic or amphiphilic acid or base or salt thereof modulates the solubility of the imaging agent and/or the pharmaceutical agent in the ICell by forming a hydrophobic ion-pair or multiple hydrophobic ion-pairs with the imaging agent and/or the pharmaceutical agent.
| Original language | English |
|---|---|
| IPC | A61P 35/ 00 A I |
| Patent number | WO2023227517 |
| Filing date | 23/05/2022 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 23/05/2022 |
| Priority number | EP20220174814 |
| Publication status | Published - 30 Nov 2023 |