Formulation of api's and excipient's in an icell via hydrophobic ion pairing

Thomas Lars Andresen (Inventor), Jonas Rosager Henriksen (Inventor), Anders Elias Hansen (Inventor), Albert Juan Fuglsang-Madsen (Inventor), Elizabeth Serrano Chávez (Inventor), Unnur Jóna Björgvinsdóttir (Inventor), Xin Li (Inventor)

Research output: Patent

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Abstract

The present invention refers to a composition forming a hydrophobic ion par (HIP), comprising: a. an imaging agent and/or a pharmaceutical agent with zwitterionic, cationic or anionic charge; b. a counterion being a hydrophobic or amphiphilic acid or base, or salt thereof; c. a non-water soluble carbohydrate; d. a non-aqueous solvent; wherein at least 30% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of disaccharides or trisaccharides, or mixtures thereof; wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 10,000 centipoise (cP) after administration to transform into an ICell; and wherein the hydrophobic or amphiphilic acid or base or salt thereof modulates the solubility of the imaging agent and/or the pharmaceutical agent in the ICell by forming a hydrophobic ion-pair or multiple hydrophobic ion-pairs with the imaging agent and/or the pharmaceutical agent.

Original languageEnglish
IPCA61P 35/ 00 A I
Patent numberWO2023227517
Filing date23/05/2022
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date23/05/2022
Priority numberEP20220174814
Publication statusPublished - 30 Nov 2023

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