Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Hyperpolarization by the dissolution dynamic nuclear polarization (DNP) technique permits the generation of high spin polarization of solution state. However, sample formulation for dissolution-DNP is often difficult, as concentration and viscosity must be optimized to yield a dissolved sample with sufficient concentration, while maintaining polarization during the dissolution process. The unique chemical properties of choline permit the generation of highly soluble salts as well as deep eutectic mixtures with carboxylic acids and urea. We describe the formulation of these samples and compare their performance to more traditional sample formulations. Choline yields stable samples with exceptional polarization performance while simultaneously offering the capability to easily remove the choline after dissolution, perform experiments with the hyperpolarized choline, or anything in between.
Original languageEnglish
JournalJournal of Magnetic Resonance
Volume236
Pages (from-to)26-30
ISSN1090-7807
DOIs
Publication statusPublished - 2013

Keywords

  • NMR
  • Hyperpolarization
  • Dynamic nuclear polarization
  • Glassing agents

Cite this

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title = "Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization",
abstract = "Hyperpolarization by the dissolution dynamic nuclear polarization (DNP) technique permits the generation of high spin polarization of solution state. However, sample formulation for dissolution-DNP is often difficult, as concentration and viscosity must be optimized to yield a dissolved sample with sufficient concentration, while maintaining polarization during the dissolution process. The unique chemical properties of choline permit the generation of highly soluble salts as well as deep eutectic mixtures with carboxylic acids and urea. We describe the formulation of these samples and compare their performance to more traditional sample formulations. Choline yields stable samples with exceptional polarization performance while simultaneously offering the capability to easily remove the choline after dissolution, perform experiments with the hyperpolarized choline, or anything in between.",
keywords = "NMR, Hyperpolarization, Dynamic nuclear polarization, Glassing agents",
author = "Sean Bowen and Ardenkj{\ae}r-Larsen, {Jan Henrik}",
year = "2013",
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language = "English",
volume = "236",
pages = "26--30",
journal = "Journal of Magnetic Resonance",
issn = "1090-7807",
publisher = "Elsevier",

}

Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization. / Bowen, Sean; Ardenkjær-Larsen, Jan Henrik.

In: Journal of Magnetic Resonance, Vol. 236, 2013, p. 26-30.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization

AU - Bowen, Sean

AU - Ardenkjær-Larsen, Jan Henrik

PY - 2013

Y1 - 2013

N2 - Hyperpolarization by the dissolution dynamic nuclear polarization (DNP) technique permits the generation of high spin polarization of solution state. However, sample formulation for dissolution-DNP is often difficult, as concentration and viscosity must be optimized to yield a dissolved sample with sufficient concentration, while maintaining polarization during the dissolution process. The unique chemical properties of choline permit the generation of highly soluble salts as well as deep eutectic mixtures with carboxylic acids and urea. We describe the formulation of these samples and compare their performance to more traditional sample formulations. Choline yields stable samples with exceptional polarization performance while simultaneously offering the capability to easily remove the choline after dissolution, perform experiments with the hyperpolarized choline, or anything in between.

AB - Hyperpolarization by the dissolution dynamic nuclear polarization (DNP) technique permits the generation of high spin polarization of solution state. However, sample formulation for dissolution-DNP is often difficult, as concentration and viscosity must be optimized to yield a dissolved sample with sufficient concentration, while maintaining polarization during the dissolution process. The unique chemical properties of choline permit the generation of highly soluble salts as well as deep eutectic mixtures with carboxylic acids and urea. We describe the formulation of these samples and compare their performance to more traditional sample formulations. Choline yields stable samples with exceptional polarization performance while simultaneously offering the capability to easily remove the choline after dissolution, perform experiments with the hyperpolarized choline, or anything in between.

KW - NMR

KW - Hyperpolarization

KW - Dynamic nuclear polarization

KW - Glassing agents

U2 - 10.1016/j.jmr.2013.08.007

DO - 10.1016/j.jmr.2013.08.007

M3 - Journal article

VL - 236

SP - 26

EP - 30

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

SN - 1090-7807

ER -