Foot-and-mouth disease

Graham Belsham, Bryan Charleston, Terry Jackson, David J Paton

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Foot-and-mouth disease is an economically important, highly contagious, disease of cloven-hoofed animals characterized by the appearance of vesicles (blisters) on the feet and in and around the mouth. The causative agent, foot-and-mouth disease virus, was the first mammalian virus to be discovered. It has a ribonucleic acid (RNA) genome enclosed within a protein coat. The virus replicates very rapidly within the cytoplasm of cells. The RNA genome has to function both as a messenger RNA and as a template for RNA replication. The RNA encodes a single polyprotein which is processed, by virus-encoded proteases, to about 12 mature products which are required for virus replication and assembly. Some of these viral proteins modify host cell activities to block anti-virus defence systems. Thus, this small virus displays a remarkably complex array of biological activities.
    Original languageEnglish
    JournalEncyclopedia of Life Sciences
    DOIs
    Publication statusE-pub ahead of print - 2009

    Cite this

    Belsham, G., Charleston, B., Jackson, T., & Paton, D. J. (2009). Foot-and-mouth disease. Encyclopedia of Life Sciences. https://doi.org/10.1002/9780470015902.a0001024.pub2