Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics.

Inge Lundt, Andreas J. Steiner, Arnold E. Stütz, Chris A. Tarling, Stefan Ully, Stephen G. Withers, Tanja M. Wrodnigg

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

1,5-Dideoxy-1,5-imino-D-glucitol, the corresponding D-manno and L-ido epimers as well as the powerful b-glucosidase inhibitor isofagomine were N-alkylated with di-, tri-, as well as tetraethylene glycol derived straight chain spacer arms by a set of simple standard procedures. The terminal functional groups of the spacer arms, primary amines, were employed to introduce fluorescent dansyl moieties. Resulting derivatives showed glycosidase inhibitory activities comparable to those of the parent compounds.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry
Volume14
Pages (from-to)1737-1742
ISSN0968-0896
Publication statusPublished - 2006

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