Fluorescent light energy in wound healing: When is a photon something more?

Michela Zago, Mehrnoush Dehghani, Joanna Jaworska, Maiken Mellergaard, Dierdre Edge, Dennis Dan Corell, Shannon E. Campbell, Søren Skov, Lise Hebert, Michael Nielsen, Michael Hamblin

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    Abstract

    Fluorescent Light Energy (FLE) is a unique form of photobiomodulation that stimulates healing, reduces inflammation, and alleviates pain. The system works by exciting a chromophore in a topical substrate, which emits FLE with a broad spectral range (∼400-700 nm) that is delivered to the target tissue below. Results from in vivo and in vitro studies have shown FLE modulates inflammation via down-regulation of pro-inflammatory cytokines such as IL-6 and TNF-α and stimulates mitochondria biogenesis1. A recent study showed FLE-stimulated cells responded more potently compared to cells treated with light from an LED light source ("Mimicking Lamp") designed to generate the same emission spectra and power intensity profile as FLE2. FLE-treated human dermal fibroblasts (HDF) experienced up-regulated collagen production, while a minor and nonsignificant effect was observed for the Mimicking Lamp-treated HDFs. These results suggest that photons generated by FLE either penetrate tissue differently or are absorbed differently compared to photons from a LED light source. Photonic properties of FLE that could impact tissue penetration or absorption may include polarity or coherency, leading to different cellular responses. To investigate if light polarity may influence cellular responses to FLE stimulation, the present study applied linear and circular-polarizing filters to investigate the influence of FLE's polarity on immune parameters. The data suggest that FLE polarity contributes to its impact on biological systems. Furthermore, the immunemodulatory impact of FLE was investgated in a pilot study on a human ex vivo skin model suggesting that central myeloid immune surface markes are modulated by FLE.

    Original languageEnglish
    Title of host publicationProceedings of SPIE
    EditorsMichael R. Hamblin, James D. Carroll, Praveen Arany
    Number of pages9
    Volume11221
    PublisherSPIE - International Society for Optical Engineering
    Publication date1 Jan 2020
    Article number112210A
    ISBN (Electronic)9781510632059
    DOIs
    Publication statusPublished - 1 Jan 2020
    EventSPIE Photonics West BiOS 2020 - The Moscone Center, San Francisco, United States
    Duration: 1 Feb 20206 Feb 2020
    https://spie.org/conferences-and-exhibitions/photonics-west/bios

    Conference

    ConferenceSPIE Photonics West BiOS 2020
    LocationThe Moscone Center
    Country/TerritoryUnited States
    CitySan Francisco
    Period01/02/202006/02/2020
    SponsorSPIE
    Internet address
    SeriesProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    ISSN1605-7422

    Keywords

    • Cellular Response
    • Fluorescence Biomodulation
    • Fluorescent Light Energy
    • Light Polarity
    • Wound Healing

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