Flow-orthogonal bead oscillation in a microfluidic chip with a magnetic anisotropic flux-guide array

Stijn Van Pelt, Roy Derks, Marco Matteucci, Mikkel Fougt Hansen, Andreas Dietzel

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    A new concept for the manipulation of superparamagnetic beads inside a microfluidic chip is presented in this paper. The concept allows for bead actuation orthogonal to the flow direction inside a microchannel. Basic manipulation functionalities were studied by means of finite element simulations and results were oval-shaped steady state oscillations with bead velocities up to 500 μm/s. The width of the trajectory could be controlled by prescribing external field rotation. Successful verification experiments were performed on a prototype chip fabricated with excimer laser ablation in polycarbonate and electroforming of nickel flux-guides. Bead velocities up to 450 μm/s were measured in a 75 μm wide channel. By prescribing the currents in the external quadrupole magnet, the shape of the bead trajectory could be controlled.
    Original languageEnglish
    JournalBiomedical Microdevices
    Volume13
    Issue number2
    Pages (from-to)353-359
    ISSN1387-2176
    DOIs
    Publication statusPublished - 2011

    Bibliographical note

    Electronic supplementary material: The online version of this article (doi:10.1007/s10544-010-9503-5) contains supplementary material, which is available to authorized users.

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