First-in-Human: Simultaneous Hyperpolarized 1-13C-Pyruvate Magnetic Resonance Spectroscopy and 18F-FDG PET (hyperPET) Imaging of a Patient With Lymphoma

Mathias Loft; Andreas Clemmensen; Emil Nørgaard Christensen; Charlotte Lund Denholt; Helle Hjorth Johannesen; Nic Gillings; Esben Andreas Carlsen; Malene Martini Clausen; Martin Hutchings; Thomas Lund Andersen; Jan Henrik Ardenkjær-Larsen; Andreas Kjaer

doi:10.1097/RLU.0000000000005534

First-in-Human: Simultaneous Hyperpolarized 1-¹³C-Pyruvate Magnetic Resonance Spectroscopy and ¹⁸F-FDG PET (hyperPET) Imaging of a Patient With Lymphoma

Mathias Loft, Andreas Clemmensen, Emil Nørgaard Christensen, Charlotte Lund Denholt, Helle Hjorth Johannesen, Nic Gillings, Esben Andreas Carlsen, Malene Martini Clausen, Martin Hutchings, Thomas Lund Andersen, Jan Henrik Ardenkjær-Larsen, Andreas Kjaer^*

^*Corresponding author for this work

University of Copenhagen

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Abstract

Hyperpolarized 1-¹³C-pyruvate magnetic resonance spectroscopy (MRS) and MRS imaging (MRSI) offer noninvasive and real-time direct assessment of the altered metabolism of cancer cells known as the Warburg effect - a key hallmark of cancer. When combined with simultaneously acquired ¹⁸F-FDG PET in a PET/MR scanner, coined hyperPET by us, this dual-modality may unveil cancer-type specific glucose metabolic phenotypes with potential implications for patient prognostication, treatment-response assessment, and prediction. We here present the first human data of simultaneously acquired hyperpolarized MRS/MRSI and PET performed in a PET/MR scanner - and the first human hyperpolarized MRS/MRSI data from a patient with lymphoma.

Original language	English
Journal	Clinical Nuclear Medicine
Volume	50
Issue number	2
Pages (from-to)	186-187
ISSN	0363-9762
DOIs	https://doi.org/10.1097/RLU.0000000000005534
Publication status	Published - 2025

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Loft, M., Clemmensen, A., Christensen, E. N., Denholt, C. L., Johannesen, H. H., Gillings, N., Carlsen, E. A., Clausen, M. M., Hutchings, M., Andersen, T. L., Ardenkjær-Larsen, J. H., & Kjaer, A. (2025). First-in-Human: Simultaneous Hyperpolarized 1-¹³C-Pyruvate Magnetic Resonance Spectroscopy and ¹⁸F-FDG PET (hyperPET) Imaging of a Patient With Lymphoma. Clinical Nuclear Medicine, 50(2), 186-187. https://doi.org/10.1097/RLU.0000000000005534

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abstract = "Hyperpolarized 1-13C-pyruvate magnetic resonance spectroscopy (MRS) and MRS imaging (MRSI) offer noninvasive and real-time direct assessment of the altered metabolism of cancer cells known as the Warburg effect - a key hallmark of cancer. When combined with simultaneously acquired 18F-FDG PET in a PET/MR scanner, coined hyperPET by us, this dual-modality may unveil cancer-type specific glucose metabolic phenotypes with potential implications for patient prognostication, treatment-response assessment, and prediction. We here present the first human data of simultaneously acquired hyperpolarized MRS/MRSI and PET performed in a PET/MR scanner - and the first human hyperpolarized MRS/MRSI data from a patient with lymphoma.",

author = "Mathias Loft and Andreas Clemmensen and Christensen, {Emil N{\o}rgaard} and Denholt, {Charlotte Lund} and Johannesen, {Helle Hjorth} and Nic Gillings and Carlsen, {Esben Andreas} and Clausen, {Malene Martini} and Martin Hutchings and Andersen, {Thomas Lund} and Ardenkj{\ae}r-Larsen, {Jan Henrik} and Andreas Kjaer",

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Loft, M, Clemmensen, A, Christensen, EN, Denholt, CL, Johannesen, HH, Gillings, N, Carlsen, EA, Clausen, MM, Hutchings, M, Andersen, TL, Ardenkjær-Larsen, JH & Kjaer, A 2025, 'First-in-Human: Simultaneous Hyperpolarized 1-¹³C-Pyruvate Magnetic Resonance Spectroscopy and ¹⁸F-FDG PET (hyperPET) Imaging of a Patient With Lymphoma', Clinical Nuclear Medicine, vol. 50, no. 2, pp. 186-187. https://doi.org/10.1097/RLU.0000000000005534

First-in-Human: Simultaneous Hyperpolarized 1-¹³C-Pyruvate Magnetic Resonance Spectroscopy and ¹⁸F-FDG PET (hyperPET) Imaging of a Patient With Lymphoma. / Loft, Mathias; Clemmensen, Andreas; Christensen, Emil Nørgaard et al.
In: Clinical Nuclear Medicine, Vol. 50, No. 2, 2025, p. 186-187.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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