Abstract
Filamentous fungi (including microorganisms such as
Aspergillus niger
and
Rhizopus oryzae) represent an enormously important platform for industrial
fermentation. Two particularly valuable features are the high yield coefficients
and the ability to secrete products. However, the
filamentous morphology,
together with non-Newtonian rheological properties (shear thinning), result in
poor oxygen transfer unless sufficient energy is provided to the fermentation.
While genomic research may improve the organisms, there is no doubt that to
enable further application in future it will be necessary to match such research
with studies of oxygen transfer and energy supply to high viscosity
fluids.
Hence, the implementation of innovative solutions (some of which in principle
are already possible) will be essential
to ensure the further development of
such fermentations.
Original language | English |
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Title of host publication | Industrial Scale Suspension Culture of Living Cells |
Editors | Hans-Peter Meyer, Diego R. Schmidhalter |
Publisher | Wiley-VCH |
Publication date | 2014 |
Pages | 130-161 |
ISBN (Print) | 978-3-527-33547-3 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Fermenter design
- Fermenter operation
- Filamentous fungi
- Industrial fermentation