Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume

Kai Buckenmaier, Anders Pedersen, Paul SanGiorgio, Klaus Scheffler, John Clarke, Ben Inglis*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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We investigate the feasibility of performing functional MRI (fMRI) at ultralow field (ULF) with a Superconducting QUantum Interference Device (SQUID), as used for detecting magnetoencephalography (MEG) signals from the human head. While there is negligible magnetic susceptibility variation to produce blood oxygenation level-dependent (BOLD) contrast at ULF, changes in cerebral blood volume (CBV) may be a sensitive mechanism for fMRI given the five-fold spread in spin-lattice relaxation time (T1) values across the constituents of the human brain. We undertook simulations of functional signal strength for a simplified brain model involving activation of a primary cortical region in a manner consistent with a blocked task experiment. Our simulations involve measured values of T1 at ULF and experimental parameters for the performance of an upgraded ULFMRI scanner. Under ideal experimental conditions we predict a functional signal-to-noise ratio of between 3.1 and 7.1 for an imaging time of 30 min, or between 1.5 and 3.5 for a blocked task experiment lasting 7.5 min. Our simulations suggest it may be feasible to perform fMRI using a ULFMRI system designed to perform MRI and MEG in situ.
Original languageEnglish
Pages (from-to)185-191
Number of pages7
Publication statusPublished - 2019


  • Cerebral blood volume
  • Ultra-low field
  • fMRI

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