Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume

Kai Buckenmaier, Anders Pedersen, Paul SanGiorgio, Klaus Scheffler, John Clarke, Ben Inglis*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

We investigate the feasibility of performing functional MRI (fMRI) at ultralow field (ULF) with a Superconducting QUantum Interference Device (SQUID), as used for detecting magnetoencephalography (MEG) signals from the human head. While there is negligible magnetic susceptibility variation to produce blood oxygenation level-dependent (BOLD) contrast at ULF, changes in cerebral blood volume (CBV) may be a sensitive mechanism for fMRI given the five-fold spread in spin-lattice relaxation time (T1) values across the constituents of the human brain. We undertook simulations of functional signal strength for a simplified brain model involving activation of a primary cortical region in a manner consistent with a blocked task experiment. Our simulations involve measured values of T1 at ULF and experimental parameters for the performance of an upgraded ULFMRI scanner. Under ideal experimental conditions we predict a functional signal-to-noise ratio of between 3.1 and 7.1 for an imaging time of 30 min, or between 1.5 and 3.5 for a blocked task experiment lasting 7.5 min. Our simulations suggest it may be feasible to perform fMRI using a ULFMRI system designed to perform MRI and MEG in situ.
Original languageEnglish
JournalNeuroImage
Volume186
Pages (from-to)185-191
Number of pages7
ISSN1053-8119
DOIs
Publication statusPublished - 2019

Keywords

  • Cerebral blood volume
  • SQUID
  • Ultra-low field
  • fMRI

Cite this

Buckenmaier, K., Pedersen, A., SanGiorgio, P., Scheffler, K., Clarke, J., & Inglis, B. (2019). Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume. NeuroImage, 186, 185-191. https://doi.org/10.1016/j.neuroimage.2018.10.071
Buckenmaier, Kai ; Pedersen, Anders ; SanGiorgio, Paul ; Scheffler, Klaus ; Clarke, John ; Inglis, Ben. / Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume. In: NeuroImage. 2019 ; Vol. 186. pp. 185-191.
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abstract = "We investigate the feasibility of performing functional MRI (fMRI) at ultralow field (ULF) with a Superconducting QUantum Interference Device (SQUID), as used for detecting magnetoencephalography (MEG) signals from the human head. While there is negligible magnetic susceptibility variation to produce blood oxygenation level-dependent (BOLD) contrast at ULF, changes in cerebral blood volume (CBV) may be a sensitive mechanism for fMRI given the five-fold spread in spin-lattice relaxation time (T1) values across the constituents of the human brain. We undertook simulations of functional signal strength for a simplified brain model involving activation of a primary cortical region in a manner consistent with a blocked task experiment. Our simulations involve measured values of T1 at ULF and experimental parameters for the performance of an upgraded ULFMRI scanner. Under ideal experimental conditions we predict a functional signal-to-noise ratio of between 3.1 and 7.1 for an imaging time of 30 min, or between 1.5 and 3.5 for a blocked task experiment lasting 7.5 min. Our simulations suggest it may be feasible to perform fMRI using a ULFMRI system designed to perform MRI and MEG in situ.",
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Buckenmaier, K, Pedersen, A, SanGiorgio, P, Scheffler, K, Clarke, J & Inglis, B 2019, 'Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume', NeuroImage, vol. 186, pp. 185-191. https://doi.org/10.1016/j.neuroimage.2018.10.071

Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume. / Buckenmaier, Kai; Pedersen, Anders; SanGiorgio, Paul; Scheffler, Klaus; Clarke, John; Inglis, Ben.

In: NeuroImage, Vol. 186, 2019, p. 185-191.

Research output: Contribution to journalJournal articleResearchpeer-review

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AU - Inglis, Ben

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