Feasibility of bovine submaxillary mucin (BSM) films as biomimetic coating for polymeric biomaterials

Seunghwan Lee, Jan Busk Madsen, Kirsi I. Pakkanen

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

Feasibility of bovine submaxillary mucin (BSM) films generated via spontaneous adsorption from aqueous solutions onto polydimethylsiloxane (PDMS) and polystyrene (PS) surfaces have been investigated as biomimetic coatings for polymeric biomaterials. Two attributes as biomedical coatings, namely anti-fouling properties and lubricity, have been focused on in this study. Optical waveguide light-mode spectroscopy (OWLS) and fluorescence microscopy studies have shown that albumin, fibrinogen, immunoglobulin G, and serum rapidly adsorb onto BSM layers formed on PDMS and PS surfaces. Pin-on-disk tribometry, employing compliant PDMS as tribopairs, has shown that BSM coatings generated on PDMS surface via spontaneous adsorption from aqueous solution has effective lubricating properties, but for very limited duration only.
Original languageEnglish
Title of host publicationProceedings of the IASTED International Conference on Biomedical Engineering, BioMed 2013
Number of pages7
Publication date2013
Pages591-597
DOIs
Publication statusPublished - 2013
EventThe 10th IASTED International Conference on Biomedical Engineering - Innsbruck, Austria
Duration: 13 Feb 201315 Feb 2013
Conference number: 10

Conference

ConferenceThe 10th IASTED International Conference on Biomedical Engineering
Number10
CountryAustria
CityInnsbruck
Period13/02/201315/02/2013

Keywords

  • Biofouling
  • Biomedical coating
  • Bovine submaxillary mucin (BSM)
  • Lubricity

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