Orientation dispersion bias in axon diameter measurements can be removed by powder averaging of the diffusion MRI signal in isotropically distributed directions, but has not been validated in complex fiber architectures. Here, we demonstrate the success of the spherical mean technique (SMT) and a recent power law (PL) implementation in removing orientation-related bias in diameter estimates of real axons from the splenium corpus callosum and a complex crossing fiber region of the vervet monkey brain. In the crossing fiber region, we find a significant population of very large axons, indicating a need for sensitivity to a wide range of diameters.
|Number of pages||3|
|Publication status||Published - 2021|
|Event||2021 ISMRM & SMRT Annual Meeting & Exhibition - Online|
Duration: 15 May 2021 → 20 May 2021
|Conference||2021 ISMRM & SMRT Annual Meeting & Exhibition|
|Period||15/05/2021 → 20/05/2021|