Feasibility of a novel liquid fiducial marker for use in image guided radiotherapy of oesophageal cancer

Steen Riisgaard de Blanck*, Jonas Scherman-Rydhög, Mette Siemsen, Merete Christensen, Lene Baeksgaard, Rasmus Irming Jølck, Lena Specht, Thomas Lars Andresen, Gitte Fredberg Persson

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    OBJECTIVE:
    To evaluate the feasibility of a new liquid fiducial marker for use in image-guided radiotherapy for oesophageal cancer.

    METHODS:
    Liquid fiducial markers were implanted in patients with metastatic or inoperable locally advanced oesophageal or gastro-oesophageal junction cancer receiving radiotherapy. Markers were implanted using a conventional gastroscope equipped with a 22 G Wang needle. Marker visibility was evaluated on fluoroscopy, CT, MRI and cone beam CT scans.

    RESULTS:
    Liquid markers (n = 16) were injected in four patients. No Grade 2 or worse adverse events were observed in relation to the implantation procedure, during treatment or in the follow-up period. 12/16 (75%) markers were available at the planning CT-scan and throughout the treatment- and follow-up period. The implanted markers were adequately visible in CT and cone beam CT but were difficult to distinguish in fluoroscopy and MRI without information from the corresponding CT image.

    CONCLUSION:
    Liquid fiducial marker placement in the oesophagus proved safe and clinically feasible.

    ADVANCES IN KNOWLEDGE:
    This paper presents the first clinical use of a new liquid fiducial marker in patients with oesophageal cancer and demonstrates that marker implantation using standard gastroscopic equipment and subsequent use in three-dimensional image-guided radiation therapy is safe and clinically feasible.
    Original languageEnglish
    Article number20180236
    JournalBritish Journal of Radiology
    Volume91
    Issue number1092
    ISSN0007-1285
    DOIs
    Publication statusPublished - 2018

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