Fast architecture-level synthesis of fault-tolerant flow-based microfluidic biochips

Wei Lun Huang, Ankur Gupta, Sudip Roy, Tsung-Yi Ho, Paul Pop

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

Microfluidic-based lab-on-a-chips have emerged as a popular technology for implementation of different biochemical test protocols used in medical diagnostics. However, in the manufacturing process or during operation of such chips, some faults may occur that leads to damage of the chip, which in turn results in wastage of expensive reagent fluids. In order to make the chip fault-tolerant, the state-of-the-art technique adopts simulated annealing (SA) based approach to synthesize a fault-tolerant architecture. However, the SA method is time consuming and non-deterministic with over-simplified model that usually derive sub-optimal results. Thus, we propose a progressive optimization procedure for the synthesis of fault-tolerant flow-based microfluidic biochips. Simulation results demonstrate that proposed method is efficient compared to the state-of-the-art techniques and can provide effective solutions in 88% (on average) less CPU time compared to state-of-the-art technique over three benchmark bioprotocols.
Original languageEnglish
Title of host publicationProceedings of the 2017 Design, Automation and Test in Europe
PublisherIEEE
Publication date2017
Article number7927262
ISBN (Print)9783981537093
DOIs
Publication statusPublished - 2017
Event20th Design, Automation and Test in Europe - SwissTech Convention Center, Lausanne, Switzerland
Duration: 27 Mar 201731 Mar 2017

Conference

Conference20th Design, Automation and Test in Europe
LocationSwissTech Convention Center
CountrySwitzerland
CityLausanne
Period27/03/201731/03/2017
SeriesProceedings of the Design, Automation, and Test in Europe Conference and Exhibition
ISSN1530-1591

Cite this

Huang, W. L., Gupta, A., Roy, S., Ho, T-Y., & Pop, P. (2017). Fast architecture-level synthesis of fault-tolerant flow-based microfluidic biochips. In Proceedings of the 2017 Design, Automation and Test in Europe [7927262] IEEE. Proceedings of the Design, Automation, and Test in Europe Conference and Exhibition https://doi.org/10.23919/DATE.2017.7927262