We studied whether the cultivated mushroom (Agaricus bisporus) or 4-(carboxy)phenylhydrazine (CP) induce lung adenomas in the A/J mouse lung tumor model. For 26 weeks female mice were fed a semisynthetic diet where 11 or 22% of the diet was replaced by freeze-dried mushrooms. The intake of the mushroom diets was equivalent to an intake of agaritine, the major phenylhydrazine derivative occurring in the mushroom, of 92 or 166 mg/kg body weight per day. The intake of CP was 106 mg/kg body weight per day. Neither the;freeze-dried mushroom nor CP induced statistically significant increased numbers of lung adenomas in female A/J mice in the administered dosages.
|Publication status||Published - 1997|
Pilegaard, K., Kristiansen, E., Meyer, O. A., & Gry, J. (1997). Failure of the cultivated mushroom (Agaricus bisporus) to induce tumors in the A/J mouse lung tumor model. Cancer Letters, 120(1), 79-85.