TY - JOUR
T1 - Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae
AU - Bahl, Martin Iain
AU - Jørgensen, Simon Mark Dahl
AU - Skriver, Alberte Hjortgård
AU - Larsen, Nanna Alsig
AU - Wang, Mikala
AU - Licht, Tine Rask
AU - Dahlerup, Jens Frederik
AU - Hvas, Christian Lodberg
PY - 2020
Y1 - 2020
N2 - Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.
AB - Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.
KW - Faecal microbiota transplantation
KW - Clostridioides difficile
KW - Klebsiella pneumoniae
KW - Drug resistance
U2 - 10.1080/00365521.2020.1753806
DO - 10.1080/00365521.2020.1753806
M3 - Journal article
C2 - 32324085
SN - 0036-5521
VL - 55
SP - 626
EP - 630
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 5
ER -