Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae

Martin Iain Bahl, Simon Mark Dahl Jørgensen, Alberte Hjortgård Skriver, Nanna Alsig Larsen, Mikala Wang, Tine Rask Licht, Jens Frederik Dahlerup, Christian Lodberg Hvas*

*Corresponding author for this work

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Abstract

Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume55
Issue number5
Pages (from-to)626-630
ISSN0036-5521
DOIs
Publication statusPublished - 2020

Keywords

  • Faecal microbiota transplantation
  • Clostridioides difficile
  • Klebsiella pneumoniae
  • Drug resistance

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