Facile Large-Scale Synthesis of 5- and 6-Carboxyfluoresceins: Application for the Preparation of New Fluorescent Dyes

Peter Hammershøj, Pramod Kumar Ek, Pernille Harris, Thomas Lars Andresen, Mads Hartvig Clausen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A series of fluorescein dyes have been prepared from a common precursor through a very simple synthetic procedure, giving access to important precursors for fluorescent probes. The method has proven an efficient access to regioisomerically pure 5- and 6-carboxyfluoresceins on a large scale, in good yields, and with high regioisomeric purity. Furthermore, we have applied the method to the development of a new type of mixed fluorescein derivatives of 5-carboxyfluorescein. We have demonstrated the scope of the procedure by synthesizing a new type of double chromophore within the fluoro-Jade family.
Original languageEnglish
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number33
Pages (from-to)7301-7309
Number of pages10
ISSN1434-193X
DOIs
Publication statusPublished - 2015

Keywords

  • Synthetic methods
  • Fluorescent probes
  • Chromophores
  • Polycycles

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