Abstract
A series of fluorescein dyes have been prepared from a common precursor through a very simple synthetic procedure, giving access to important precursors for fluorescent probes. The method has proven an efficient access to regioisomerically pure 5- and 6-carboxyfluoresceins on a large scale, in good yields, and with high regioisomeric purity. Furthermore, we have applied the method to the development of a new type of mixed fluorescein derivatives of 5-carboxyfluorescein. We have demonstrated the scope of the procedure by synthesizing a new type of double chromophore within the fluoro-Jade family.
Original language | English |
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Journal | European Journal of Organic Chemistry |
Volume | 2015 |
Issue number | 33 |
Pages (from-to) | 7301-7309 |
Number of pages | 10 |
ISSN | 1434-193X |
DOIs | |
Publication status | Published - 2015 |
Keywords
- Synthetic methods
- Fluorescent probes
- Chromophores
- Polycycles