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Recently, microcontainers were introduced as a novel approach to obtain unidirectional release to avoid luminal drug loss, enhance drug permeation, protect drug payload from the harsh environment of the stomach and explore the ability for targeted drug delivery. However, in order to eventually pave the way for real life applications of these microfabricated drug delivery systems, it is necessary to fabricate them in biodegradable materials approved for similar applications and with strategies that potentially allow for largescale production. Therefore, the main focus of this work was directed towards the fabrication and characterization of biodegradable microcontainers for oral drug delivery. Small, asymmetric poly-ε-caprolactone (PCL) microcontainers were fabricated with a novel single-step hot punching process. The microcontainers were loaded with a drug and sealed to protect the drug until it reached the desired location in the gastrointestinal tract. In vitro dissolution studies were performed to assess the suitability of the microcontainers for oral drug delivery. Finally, in vivo studies in rats showed a higher bioavailability compared to conventional dosage forms and confirmed the potential of biodegradable microcontainers for oral drug delivery.
|Number of pages||162|
|Publication status||Published - 2020|