Fabrication, characterization and evaluation of bacterial cellulose-based capsule shells for oral drug delivery

Hanif Ullah, Munair Badshah, Ermei Mäkilä, Jarno Salonen, Mohammad-Ali Shahbazi, Hélder A. Santos, Taous Khan

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Bacterial cellulose (BC) was investigated for the first time for the preparation of capsule shells for immediate and sustained release of drugs. The prepared capsule shells were characterized using X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy. The BC capsule shells were studied for drug release using an USP type-I dissolution apparatus. Irrespective of the drying method and the thickness of the BC sheet, the capsule shells displayed an immediate drug release profile. Moreover, the addition of release-retardant cellulosic polymers sustained the drug release having first-order kinetics for hydroxypropylmethylcellulose and carboxymethyl cellulose sodium with R2 values of 0.9995 and 0.9954, respectively. Furthermore, these capsules shells remained buoyant in 0.1 N HCl (pH 1.2) solution up to 12 h. This study showed that BC is a promising alternative to gelatin capsules with both immediate and sustained drug release properties depending upon the compositions of the encapsulated materials.
    Original languageEnglish
    JournalCellulose
    Volume24
    Issue number3
    Pages (from-to)1445–1454
    Number of pages10
    ISSN0969-0239
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Bacterial cellulose
    • Capsule
    • Dissolution profiles
    • Membrane controlled matrix

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