Abstract
There are certain unique aspects regarding silica nanoparticles (SNPs) which make them good candidates as drug-delivery systems, such as their large specific surface areas, good chemical and physical stability and the possibili
ty to tune both pore sizes and surface polarities. Until now, SNPs have shown promise in magnetic resonance imaging, biosensors and drug delivery. The purpose of drug-delivery systems is to protect active principles by slowing down
their metabolisation rate and to release them to the targeted sites on the basis of specific interactions, leading to an important decrease in toxicity. This is an essential step in the administration of anticancer drugs, which have severe
adverse effects. The goal of our research is to develop SNPs which can be used in the targeted delivery of antineoplastic drugs. Active substances from the taxane class of drugs (such as paclitaxel or docetaxel) or anti-topoisomerase I drugs (such as camptothecin) were encapsulated into colloidal vehicles of modified silica nanoparticles . SNPs of tuned sizes were prepared through a controlled synthesis in water-in-oil microemulsions. The use of silane precursors of different polarities allowed the incorporation of both hydrophobic and hydrophilic active principles. The SNPs obtained have sizes
in the range of 20 to 50 nm and a remarkable stability in aqueous environments.
The amine functionalized surface of the SNPs was obtained by using oregano-modified silane precursor and used for further attachment of the bioligand.
ty to tune both pore sizes and surface polarities. Until now, SNPs have shown promise in magnetic resonance imaging, biosensors and drug delivery. The purpose of drug-delivery systems is to protect active principles by slowing down
their metabolisation rate and to release them to the targeted sites on the basis of specific interactions, leading to an important decrease in toxicity. This is an essential step in the administration of anticancer drugs, which have severe
adverse effects. The goal of our research is to develop SNPs which can be used in the targeted delivery of antineoplastic drugs. Active substances from the taxane class of drugs (such as paclitaxel or docetaxel) or anti-topoisomerase I drugs (such as camptothecin) were encapsulated into colloidal vehicles of modified silica nanoparticles . SNPs of tuned sizes were prepared through a controlled synthesis in water-in-oil microemulsions. The use of silane precursors of different polarities allowed the incorporation of both hydrophobic and hydrophilic active principles. The SNPs obtained have sizes
in the range of 20 to 50 nm and a remarkable stability in aqueous environments.
The amine functionalized surface of the SNPs was obtained by using oregano-modified silane precursor and used for further attachment of the bioligand.
| Original language | English |
|---|---|
| Publication date | 2014 |
| Number of pages | 1 |
| Publication status | Published - 2014 |
| Externally published | Yes |
| Event | 15th International Conference of Physical Chemistry - Bucharest, Romania Duration: 11 Sept 2014 → 13 Sept 2014 Conference number: 15 |
Conference
| Conference | 15th International Conference of Physical Chemistry |
|---|---|
| Number | 15 |
| Country/Territory | Romania |
| City | Bucharest |
| Period | 11/09/2014 → 13/09/2014 |