Fabrication and characterization of silica nanoparticles used as drug-delivery systems for antineoplastic drugs of various polarities

Ada-Ioana Bunea, Otilia Cinteza

Research output: Contribution to conferencePosterResearchpeer-review

Abstract

There are certain unique aspects regarding silica nanoparticles (SNPs) which make them good candidates as drug-delivery systems, such as their large specific surface areas, good chemical and physical stability and the possibili
ty to tune both pore sizes and surface polarities. Until now, SNPs have shown promise in magnetic resonance imaging, biosensors and drug delivery. The purpose of drug-delivery systems is to protect active principles by slowing down
their metabolisation rate and to release them to the targeted sites on the basis of specific interactions, leading to an important decrease in toxicity. This is an essential step in the administration of anticancer drugs, which have severe
adverse effects. The goal of our research is to develop SNPs which can be used in the targeted delivery of antineoplastic drugs. Active substances from the taxane class of drugs (such as paclitaxel or docetaxel) or anti-topoisomerase I drugs (such as camptothecin) were encapsulated into colloidal vehicles of modified silica nanoparticles . SNPs of tuned sizes were prepared through a controlled synthesis in water-in-oil microemulsions. The use of silane precursors of different polarities allowed the incorporation of both hydrophobic and hydrophilic active principles. The SNPs obtained have sizes
in the range of 20 to 50 nm and a remarkable stability in aqueous environments.
The amine functionalized surface of the SNPs was obtained by using oregano-modified silane precursor and used for further attachment of the bioligand.
Original languageEnglish
Publication date2014
Number of pages1
Publication statusPublished - 2014
Externally publishedYes
EventInternational Conference of Physical Chemistry - Bucharest, Romania
Duration: 11 Sep 201413 Sep 2014
Conference number: 15

Conference

ConferenceInternational Conference of Physical Chemistry
Number15
CountryRomania
CityBucharest
Period11/09/201413/09/2014

Fingerprint Dive into the research topics of 'Fabrication and characterization of silica nanoparticles used as drug-delivery systems for antineoplastic drugs of various polarities'. Together they form a unique fingerprint.

Cite this