Exposure to the thyroperoxidase inhibitors methimazole and amitrole disrupts testis development in rats

Ida S. W. Strand; Monica Kam Draskau; Anne-Sofie Ballegaard; Raul Davila; Louise Ramhøj; Marta Axelstad; Sofie Rising; Bertrand Evrard; Cassy M. Spiller; Josephine Bowles; Frédéric Chalmel; Terje Svingen

Exposure to the thyroperoxidase inhibitors methimazole and amitrole disrupts testis development in rats

Ida S. W. Strand^*, Monica Kam Draskau, Anne-Sofie Ballegaard, Raul Davila, Louise Ramhøj, Marta Axelstad, Sofie Rising, Bertrand Evrard, Cassy M. Spiller, Josephine Bowles, Frédéric Chalmel, Terje Svingen

^*Corresponding author for this work

Research output: Contribution to conference › Poster › Research

Abstract

Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system and affect testicular growth and physiology in developing rodents and humans. The thyroperoxidase (TPO) inhibitor propyltiouracil (PTU) induces transient hypothyroidism in perinatal rat pups and has been associated with a reduction in testes size and changes to the testicular cell populations. While TH is known to influence testicular development, the underlying molecular mechanisms remain unclear. To address this, we investigated the effects of developmental hypothyroidism on postnatal rat testicles using two TPO-inhibitors; the pharmaceutical methimazole (MMI) and the pesticide amitrole.

Original language	English
Publication date	2023
Number of pages	1
Publication status	Published - 2023
Event	NorthTox 2023: Toxicology in the Anthropocene - Stockholm University, Stockholm, Sweden Duration: 20 Apr 2023 → 21 Apr 2023

Conference

Conference	NorthTox 2023
Location	Stockholm University
Country/Territory	Sweden
City	Stockholm
Period	20/04/2023 → 21/04/2023

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title = "Exposure to the thyroperoxidase inhibitors methimazole and amitrole disrupts testis development in rats",

abstract = "Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system and affect testicular growth and physiology in developing rodents and humans. The thyroperoxidase (TPO) inhibitor propyltiouracil (PTU) induces transient hypothyroidism in perinatal rat pups and has been associated with a reduction in testes size and changes to the testicular cell populations. While TH is known to influence testicular development, the underlying molecular mechanisms remain unclear. To address this, we investigated the effects of developmental hypothyroidism on postnatal rat testicles using two TPO-inhibitors; the pharmaceutical methimazole (MMI) and the pesticide amitrole.",

author = "Strand, {Ida S. W.} and Draskau, {Monica Kam} and Anne-Sofie Ballegaard and Raul Davila and Louise Ramh{\o}j and Marta Axelstad and Sofie Rising and Bertrand Evrard and Spiller, {Cassy M.} and Josephine Bowles and Fr{\'e}d{\'e}ric Chalmel and Terje Svingen",

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language = "English",

note = "NorthTox 2023 : Toxicology in the Anthropocene, NorthTox2023 ; Conference date: 20-04-2023 Through 21-04-2023",

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TY - CONF

T1 - Exposure to the thyroperoxidase inhibitors methimazole and amitrole disrupts testis development in rats

AU - Strand, Ida S. W.

AU - Draskau, Monica Kam

AU - Ballegaard, Anne-Sofie

AU - Davila, Raul

AU - Ramhøj, Louise

AU - Axelstad, Marta

AU - Rising, Sofie

AU - Evrard, Bertrand

AU - Spiller, Cassy M.

AU - Bowles, Josephine

AU - Chalmel, Frédéric

AU - Svingen, Terje

PY - 2023

Y1 - 2023

N2 - Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system and affect testicular growth and physiology in developing rodents and humans. The thyroperoxidase (TPO) inhibitor propyltiouracil (PTU) induces transient hypothyroidism in perinatal rat pups and has been associated with a reduction in testes size and changes to the testicular cell populations. While TH is known to influence testicular development, the underlying molecular mechanisms remain unclear. To address this, we investigated the effects of developmental hypothyroidism on postnatal rat testicles using two TPO-inhibitors; the pharmaceutical methimazole (MMI) and the pesticide amitrole.

AB - Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system and affect testicular growth and physiology in developing rodents and humans. The thyroperoxidase (TPO) inhibitor propyltiouracil (PTU) induces transient hypothyroidism in perinatal rat pups and has been associated with a reduction in testes size and changes to the testicular cell populations. While TH is known to influence testicular development, the underlying molecular mechanisms remain unclear. To address this, we investigated the effects of developmental hypothyroidism on postnatal rat testicles using two TPO-inhibitors; the pharmaceutical methimazole (MMI) and the pesticide amitrole.

M3 - Poster

T2 - NorthTox 2023

Y2 - 20 April 2023 through 21 April 2023

ER -

Exposure to the thyroperoxidase inhibitors methimazole and amitrole disrupts testis development in rats

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