Exposure to gestational diabetes is a stronger predictor of dysmetabolic traits in children than size at birth

Freja Bach Kampmann*, Anne Cathrine Baun Thuesen, Line Hjort, Sjurdur Frodi Olsen, Sara Monteiro Pires, Inge Tetens, Louise Groth Grunnet

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Context and Objective
Being born small or large for gestational age and intrauterine exposure to gestational diabetes (GDM) increase the risk of type 2 diabetes (T2D) in the offspring, however, the potential combined deleterious effects of size at birth and GDM exposure remains unknown.

We aimed to examine the independent effect of size at birth as well as the influence of GDM exposure in utero on cardio-metabolic traits, body composition, and puberty status in children.

Design, Participants and Methods
This study is a longitudinal birth cohort study. We used clinical data from 490 offspring of mothers with GDM and 527 control offspring aged 9-16 years, born singleton at term from the Danish National Birth Cohort with available birth weight data.

Results
We found no evidence of a U-shaped association between size at birth (expressed as birth weight, sex and gestational age adjusted z-score) and cardio-metabolic traits. Body size in childhood and adolescence reflected size at birth, but was not reflected in any metabolic outcome. No synergistic adverse effect of being born small or large for gestational age and being exposed to GDM was shown. However, GDM was associated with an adverse metabolic profile and earlier onset of female puberty in childhood and adolescence independently of size at birth.

Conclusion
In childhood and adolescence, GDM is a stronger predictor of dysmetabolic traits than size at birth. The combination of being born small or large and being exposed to GDM does not exacerbate the metabolic profile in the offspring.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume104
Issue number5
Pages (from-to)1766-1776
ISSN0021-972X
DOIs
Publication statusPublished - 2019

Cite this

Bach Kampmann, Freja ; Thuesen, Anne Cathrine Baun ; Hjort, Line ; Olsen, Sjurdur Frodi ; Pires, Sara Monteiro ; Tetens, Inge ; Grunnet, Louise Groth. / Exposure to gestational diabetes is a stronger predictor of dysmetabolic traits in children than size at birth. In: Journal of Clinical Endocrinology and Metabolism. 2019 ; Vol. 104, No. 5. pp. 1766-1776.
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title = "Exposure to gestational diabetes is a stronger predictor of dysmetabolic traits in children than size at birth",
abstract = "Context and ObjectiveBeing born small or large for gestational age and intrauterine exposure to gestational diabetes (GDM) increase the risk of type 2 diabetes (T2D) in the offspring, however, the potential combined deleterious effects of size at birth and GDM exposure remains unknown.We aimed to examine the independent effect of size at birth as well as the influence of GDM exposure in utero on cardio-metabolic traits, body composition, and puberty status in children.Design, Participants and MethodsThis study is a longitudinal birth cohort study. We used clinical data from 490 offspring of mothers with GDM and 527 control offspring aged 9-16 years, born singleton at term from the Danish National Birth Cohort with available birth weight data.ResultsWe found no evidence of a U-shaped association between size at birth (expressed as birth weight, sex and gestational age adjusted z-score) and cardio-metabolic traits. Body size in childhood and adolescence reflected size at birth, but was not reflected in any metabolic outcome. No synergistic adverse effect of being born small or large for gestational age and being exposed to GDM was shown. However, GDM was associated with an adverse metabolic profile and earlier onset of female puberty in childhood and adolescence independently of size at birth.ConclusionIn childhood and adolescence, GDM is a stronger predictor of dysmetabolic traits than size at birth. The combination of being born small or large and being exposed to GDM does not exacerbate the metabolic profile in the offspring.",
author = "{Bach Kampmann}, Freja and Thuesen, {Anne Cathrine Baun} and Line Hjort and Olsen, {Sjurdur Frodi} and Pires, {Sara Monteiro} and Inge Tetens and Grunnet, {Louise Groth}",
year = "2019",
doi = "10.1210/jc.2018-02044",
language = "English",
volume = "104",
pages = "1766--1776",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
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}

Exposure to gestational diabetes is a stronger predictor of dysmetabolic traits in children than size at birth. / Bach Kampmann, Freja; Thuesen, Anne Cathrine Baun; Hjort, Line; Olsen, Sjurdur Frodi; Pires, Sara Monteiro; Tetens, Inge; Grunnet, Louise Groth.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 104, No. 5, 2019, p. 1766-1776.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Exposure to gestational diabetes is a stronger predictor of dysmetabolic traits in children than size at birth

AU - Bach Kampmann, Freja

AU - Thuesen, Anne Cathrine Baun

AU - Hjort, Line

AU - Olsen, Sjurdur Frodi

AU - Pires, Sara Monteiro

AU - Tetens, Inge

AU - Grunnet, Louise Groth

PY - 2019

Y1 - 2019

N2 - Context and ObjectiveBeing born small or large for gestational age and intrauterine exposure to gestational diabetes (GDM) increase the risk of type 2 diabetes (T2D) in the offspring, however, the potential combined deleterious effects of size at birth and GDM exposure remains unknown.We aimed to examine the independent effect of size at birth as well as the influence of GDM exposure in utero on cardio-metabolic traits, body composition, and puberty status in children.Design, Participants and MethodsThis study is a longitudinal birth cohort study. We used clinical data from 490 offspring of mothers with GDM and 527 control offspring aged 9-16 years, born singleton at term from the Danish National Birth Cohort with available birth weight data.ResultsWe found no evidence of a U-shaped association between size at birth (expressed as birth weight, sex and gestational age adjusted z-score) and cardio-metabolic traits. Body size in childhood and adolescence reflected size at birth, but was not reflected in any metabolic outcome. No synergistic adverse effect of being born small or large for gestational age and being exposed to GDM was shown. However, GDM was associated with an adverse metabolic profile and earlier onset of female puberty in childhood and adolescence independently of size at birth.ConclusionIn childhood and adolescence, GDM is a stronger predictor of dysmetabolic traits than size at birth. The combination of being born small or large and being exposed to GDM does not exacerbate the metabolic profile in the offspring.

AB - Context and ObjectiveBeing born small or large for gestational age and intrauterine exposure to gestational diabetes (GDM) increase the risk of type 2 diabetes (T2D) in the offspring, however, the potential combined deleterious effects of size at birth and GDM exposure remains unknown.We aimed to examine the independent effect of size at birth as well as the influence of GDM exposure in utero on cardio-metabolic traits, body composition, and puberty status in children.Design, Participants and MethodsThis study is a longitudinal birth cohort study. We used clinical data from 490 offspring of mothers with GDM and 527 control offspring aged 9-16 years, born singleton at term from the Danish National Birth Cohort with available birth weight data.ResultsWe found no evidence of a U-shaped association between size at birth (expressed as birth weight, sex and gestational age adjusted z-score) and cardio-metabolic traits. Body size in childhood and adolescence reflected size at birth, but was not reflected in any metabolic outcome. No synergistic adverse effect of being born small or large for gestational age and being exposed to GDM was shown. However, GDM was associated with an adverse metabolic profile and earlier onset of female puberty in childhood and adolescence independently of size at birth.ConclusionIn childhood and adolescence, GDM is a stronger predictor of dysmetabolic traits than size at birth. The combination of being born small or large and being exposed to GDM does not exacerbate the metabolic profile in the offspring.

U2 - 10.1210/jc.2018-02044

DO - 10.1210/jc.2018-02044

M3 - Journal article

C2 - 30521046

VL - 104

SP - 1766

EP - 1776

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -