Exposure to a glyphosate-based herbicide formulation, but not glyphosate alone, has only minor effects on adult rat testis

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Abstract

Glyphosate has been suggested to be an endocrine disrupting chemical capable of disrupting male reproduction. There are conflicting data, however, with studies reporting on effects from exposure to either glyphosate alone or to herbicide formulations, making comparisons difficult. We assessed rat testis histopathology and androgen function following two weeks exposure to either glyphosate at 2.5 and 25 mg/kg bw/day (5x and 50x Acceptable Daily Intake, ADI, respectively), or equivalent high dose of glyphosate in a herbicide formulation; Glyfonova. We observed no significant effects on testes or testosterone synthesis in rats exposed to glyphosate. Limited effects were observed in rats exposed to Glyfonova, with a small upregulation of the steroidogenic genes Cyp11a1 and Cyp17a1. We conclude that glyphosate alone has no effects on adult rat testis at exposure levels up to 25 mg/kg bw/day. Glyfonova induced only minor effects on steroidogenic gene expression, likely caused by additives other than glyphosate.
Original languageEnglish
JournalReproductive Toxicology
Volume82
Pages (from-to)25-31
Number of pages7
ISSN0890-6238
DOIs
Publication statusPublished - 2018

Keywords

  • Glyphosate
  • Testis
  • Androgens
  • Pesticides
  • Testosterone
  • Steroidogenesis
  • Toxicology

Cite this

@article{92f114a2dc844f829fbc5e08e831f26a,
title = "Exposure to a glyphosate-based herbicide formulation, but not glyphosate alone, has only minor effects on adult rat testis",
abstract = "Glyphosate has been suggested to be an endocrine disrupting chemical capable of disrupting male reproduction. There are conflicting data, however, with studies reporting on effects from exposure to either glyphosate alone or to herbicide formulations, making comparisons difficult. We assessed rat testis histopathology and androgen function following two weeks exposure to either glyphosate at 2.5 and 25 mg/kg bw/day (5x and 50x Acceptable Daily Intake, ADI, respectively), or equivalent high dose of glyphosate in a herbicide formulation; Glyfonova. We observed no significant effects on testes or testosterone synthesis in rats exposed to glyphosate. Limited effects were observed in rats exposed to Glyfonova, with a small upregulation of the steroidogenic genes Cyp11a1 and Cyp17a1. We conclude that glyphosate alone has no effects on adult rat testis at exposure levels up to 25 mg/kg bw/day. Glyfonova induced only minor effects on steroidogenic gene expression, likely caused by additives other than glyphosate.",
keywords = "Glyphosate, Testis, Androgens, Pesticides, Testosterone, Steroidogenesis, Toxicology",
author = "Johansson, {Hanna Katarina Lilith} and Schwartz, {Camilla Lindgren} and Nielsen, {Lene N{\o}rby} and Julie Boberg and Vinggaard, {Anne Marie} and Bahl, {Martin Iain} and Terje Svingen",
year = "2018",
doi = "10.1016/j.reprotox.2018.09.008",
language = "English",
volume = "82",
pages = "25--31",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",

}

TY - JOUR

T1 - Exposure to a glyphosate-based herbicide formulation, but not glyphosate alone, has only minor effects on adult rat testis

AU - Johansson, Hanna Katarina Lilith

AU - Schwartz, Camilla Lindgren

AU - Nielsen, Lene Nørby

AU - Boberg, Julie

AU - Vinggaard, Anne Marie

AU - Bahl, Martin Iain

AU - Svingen, Terje

PY - 2018

Y1 - 2018

N2 - Glyphosate has been suggested to be an endocrine disrupting chemical capable of disrupting male reproduction. There are conflicting data, however, with studies reporting on effects from exposure to either glyphosate alone or to herbicide formulations, making comparisons difficult. We assessed rat testis histopathology and androgen function following two weeks exposure to either glyphosate at 2.5 and 25 mg/kg bw/day (5x and 50x Acceptable Daily Intake, ADI, respectively), or equivalent high dose of glyphosate in a herbicide formulation; Glyfonova. We observed no significant effects on testes or testosterone synthesis in rats exposed to glyphosate. Limited effects were observed in rats exposed to Glyfonova, with a small upregulation of the steroidogenic genes Cyp11a1 and Cyp17a1. We conclude that glyphosate alone has no effects on adult rat testis at exposure levels up to 25 mg/kg bw/day. Glyfonova induced only minor effects on steroidogenic gene expression, likely caused by additives other than glyphosate.

AB - Glyphosate has been suggested to be an endocrine disrupting chemical capable of disrupting male reproduction. There are conflicting data, however, with studies reporting on effects from exposure to either glyphosate alone or to herbicide formulations, making comparisons difficult. We assessed rat testis histopathology and androgen function following two weeks exposure to either glyphosate at 2.5 and 25 mg/kg bw/day (5x and 50x Acceptable Daily Intake, ADI, respectively), or equivalent high dose of glyphosate in a herbicide formulation; Glyfonova. We observed no significant effects on testes or testosterone synthesis in rats exposed to glyphosate. Limited effects were observed in rats exposed to Glyfonova, with a small upregulation of the steroidogenic genes Cyp11a1 and Cyp17a1. We conclude that glyphosate alone has no effects on adult rat testis at exposure levels up to 25 mg/kg bw/day. Glyfonova induced only minor effects on steroidogenic gene expression, likely caused by additives other than glyphosate.

KW - Glyphosate

KW - Testis

KW - Androgens

KW - Pesticides

KW - Testosterone

KW - Steroidogenesis

KW - Toxicology

U2 - 10.1016/j.reprotox.2018.09.008

DO - 10.1016/j.reprotox.2018.09.008

M3 - Journal article

VL - 82

SP - 25

EP - 31

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -