Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria

Eveline Marie Lammens, Pablo Ivan Nikel, Rob Lavigne*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Non-model bacteria like Pseudomonas putida, Lactococcus lactis and other species have unique and versatile metabolisms, offering unique opportunities for Synthetic Biology (SynBio). However, key genome editing and recombineering tools require optimization and large-scale multiplexing to unlock the full SynBio potential of these bacteria. In addition, the limited availability of a set of characterized, species-specific biological parts hampers the construction of reliable genetic circuitry. Mining of currently available, diverse bacteriophages could complete the SynBio toolbox, as they constitute an unexplored treasure trove for fully adapted metabolic modulators and orthogonally-functioning parts, driven by the longstanding co-evolution between phage and host.
Original languageEnglish
Article number5294
JournalNature Communications
Volume11
Issue number1
Number of pages14
ISSN2041-1723
DOIs
Publication statusPublished - 2020

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