Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

S. Holm Nielsen*, L Jonasson, K. Kalogeropoulos, M. A. Karsdal, A. L. Reese-Petersen, U. auf dem Keller, F. Genovese, J. Nilsson, I. Goncalves

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

Abstract

Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.
Original languageEnglish
JournalJournal of Internal Medicine
Volume287
Issue number5
Pages (from-to)493-513
Number of pages21
ISSN0954-6820
DOIs
Publication statusPublished - 2020

Keywords

  • Atherosclerosis
  • Biomarkers
  • Extracellular matrix
  • Outcome
  • Vulnerable plaque

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