Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

Meryem Benmarce; Kim Henriksen; Morten Karsdal; Signe Holm Nielsen

doi:10.3389/fneur.2025.1566228

Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

Meryem Benmarce^*
, Kim Henriksen
, Morten Karsdal
, Signe Holm Nielsen

^*Corresponding author for this work

Department of Health Technology

Roskilde University
Nordic Bioscience AS

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson’s disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all p < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.

Original language	English
Article number	1566228
Journal	Frontiers in Neurology
Volume	16
Number of pages	5
ISSN	1664-2295
DOIs	https://doi.org/10.3389/fneur.2025.1566228
Publication status	Published - 2025

Keywords

Biomarker
C1M
Parkinson’s disease
Tau-A
Tau-C

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title = "Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson{\textquoteright}s disease",

abstract = "Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson{\textquoteright}s disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all p < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.",

keywords = "Biomarker, C1M, Parkinson{\textquoteright}s disease, Tau-A, Tau-C",

author = "Meryem Benmarce and Kim Henriksen and Morten Karsdal and \{Holm Nielsen\}, Signe",

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doi = "10.3389/fneur.2025.1566228",

language = "English",

volume = "16",

journal = "Frontiers in Neurology",

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T1 - Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

AU - Benmarce, Meryem

AU - Henriksen, Kim

AU - Karsdal, Morten

AU - Holm Nielsen, Signe

PY - 2025

Y1 - 2025

N2 - Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson’s disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all p < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.

AB - Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson’s disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all p < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.

KW - Biomarker

KW - C1M

KW - Parkinson’s disease

KW - Tau-A

KW - Tau-C

U2 - 10.3389/fneur.2025.1566228

DO - 10.3389/fneur.2025.1566228

M3 - Journal article

C2 - 40371089

AN - SCOPUS:105005291383

SN - 1664-2295

VL - 16

JO - Frontiers in Neurology

JF - Frontiers in Neurology

M1 - 1566228

ER -

Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

Abstract

Keywords

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