Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines

Scott Edmonds, Alessia Volpe, Hilary Shmeeda, Ana C. Parente-Pereira, Riya Radia, Julia Baguña-Torres, Istvan Szanda, Gregory Severin, Lefteris Livieratos, Philip J. Blower, John Maher, Gilbert O. Fruhwirth, Alberto Gabizon, Rafael T.M. de Rosales

    Research output: Contribution to journalJournal articleResearchpeer-review

    260 Downloads (Pure)

    Abstract

    The clinical value of current and future nanomedicines can be improved by introducing patient selection strategies based on noninvasive sensitive whole-body imaging techniques such as positron emission tomography (PET). Thus, a broad method to radiolabel and track preformed nanomedicines such as liposomal drugs with PET radionuclides will have a wide impact in nanomedicine. Here, we introduce a simple and efficient PET radiolabeling method that exploits the metal-chelating properties of certain drugs (e.g., bisphosphonates such as alendronate and anthracyclines such as doxorubicin) and widely used ionophores to achieve excellent radiolabeling yields, purities, and stabilities with 89Zr, 52Mn, and 64Cu, and without the requirement of modification of the nanomedicine components. In a model of metastatic breast cancer, we demonstrate that this technique allows quantification of the biodistribution of a radiolabeled stealth liposomal nanomedicine containing alendronate that shows high uptake in primary tumors and metastatic organs. The versatility, efficiency, simplicity, and GMP compatibility of this method may enable submicrodosing imaging studies of liposomal nanomedicines containing chelating drugs in humans and may have clinical impact by facilitating the introduction of image-guided therapeutic strategies in current and future nanomedicine clinical studies.
    Original languageEnglish
    JournalA C S Nano
    Volume10
    Issue number11
    Pages (from-to)10294-10307
    ISSN1936-0851
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Nanomedicine
    • PET imaging
    • Tumor
    • Metastatis
    • Drug delivery
    • Liposomes

    Fingerprint

    Dive into the research topics of 'Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines'. Together they form a unique fingerprint.

    Cite this