Exploiting the genetic potential of polyketide producing streptomycetes

Tilmann Weber, K. Welzel, S. Pelzer, A. Vente, W. Wohlleben

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Streptomycetes are the most important bacterial producers of bioactive secondary metabolites such as antibiotics or cytostatics. Due to the emerging resistance of pathogenic bacteria to all commonly used antibiotics, new and modified natural compounds are required for the development of novel drugs. In addition to the classical screening for natural compounds, genome driven approaches like combinatorial biosynthesis are permanently gaining relevance for the generation of new structures. This technology utilizes the combination of genes from different biosynthesis pathways resulting in the production of novel or modified metabolites. The basis for this strategy is the access to a significant number of genes and the knowledge about the activity and specificity of the enzymes encoded by them. A joint initiative was started to exploit the biosynthesis gene clusters from streptomycetes. In this publication, an overview of the strategy for the identification and characterization of numerous biosynthesis gene clusters for polyketides displaying interesting functions and particular structural features is given
Original languageEnglish
JournalJournal of Biotechnology
Volume106
Pages (from-to)221-232
Number of pages12
ISSN0168-1656
DOIs
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • activity antibiotic Antibiotics Bacteria bacterium biosynthesis characterization development enzyme enzymes function gene gene cluster Genes Genome Identification Metabolite metabolites number polyketide polyketides production resistance screening Secondary metabolite secondary metabolites specificity strategies streptomycete Streptomycetes structure Technology

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