Sixteen subjects evaluated the indoor environment in four experiments with different combinations of ventilation systems and radiant heating/cooling systems. In the first two tests, the simulated residential room was equipped either by a mixing ventilation system supplying warm air for space heating or by a combination of radiant floor heating and mixing ventilation system. The vertical air temperature distribution was more uniform for floor heating. The discomfort due to cold feet/lower legs was higher for warm air heating, but no significant difference in thermal perceptions between the two mixing ventilation systems was found. The next two tests simulated an office room during summer, ventilated and cooled either by a displacement ventilation system alone or by a displacement ventilation system combined with radiant floor cooling. Displacement ventilation combined with floor cooling had lower floor temperature, warmer supply air, and less homogeneous vertical temperature profile, but it did not result in thermal discomfort on feet/lower legs or discomfort due to a vertical air temperature difference higher than for a displacement ventilation system alone, where the floor temperature was higher, supply air cooler, and vertical temperature profile more uniform.