Experimental implementation and proof of principle for a radionuclidic purity test solely based on half-life measurement

Thomas Jørgensen, Mikael Jensen

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    Abstract

    In this paper we present the results of an experimental implementation of the method (Jorgensen et al., 2012) for testing the radionuclidic purity (RNP) of F-18 compounds.The overall limitations of the experimental methods and their possible impacts on RNP detectability have been identified. We have developed an GUI application for use as an easy and automated test tool in the production procedure.The test results show that this method fully complies with the requirements in the European Pharmacopoeia (Eur. Ph.) for RNP of FDG and F-18 Sodium Fluoride. (C) 2015 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    JournalApplied Radiation and Isotopes
    Volume108
    Pages (from-to)108-115
    Number of pages8
    ISSN0969-8043
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Deadtime correction
    • F-18
    • Half life
    • Radionuclidic purity
    • Software
    • Statistical test

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