Experimental implementation and proof of principle for a radionuclidic purity test solely based on half-life measurement

Thomas Jørgensen; Mikael Jensen

doi:10.1016/j.apradiso.2015.12.038

Experimental implementation and proof of principle for a radionuclidic purity test solely based on half-life measurement

Thomas Jørgensen, Mikael Jensen

Technical University of Denmark

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Abstract

In this paper we present the results of an experimental implementation of the method (Jorgensen et al., 2012) for testing the radionuclidic purity (RNP) of F-18 compounds.The overall limitations of the experimental methods and their possible impacts on RNP detectability have been identified. We have developed an GUI application for use as an easy and automated test tool in the production procedure.The test results show that this method fully complies with the requirements in the European Pharmacopoeia (Eur. Ph.) for RNP of FDG and F-18 Sodium Fluoride. (C) 2015 Elsevier Ltd. All rights reserved.

Original language	English
Journal	Applied Radiation and Isotopes
Volume	108
Pages (from-to)	108-115
Number of pages	8
ISSN	0969-8043
DOIs	https://doi.org/10.1016/j.apradiso.2015.12.038
Publication status	Published - 2016

Keywords

Deadtime correction
F-18
Half life
Radionuclidic purity
Software
Statistical test

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RNP software 3Accepted author manuscript, 1.17 MB

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abstract = "In this paper we present the results of an experimental implementation of the method (Jorgensen et al., 2012) for testing the radionuclidic purity (RNP) of F-18 compounds.The overall limitations of the experimental methods and their possible impacts on RNP detectability have been identified. We have developed an GUI application for use as an easy and automated test tool in the production procedure.The test results show that this method fully complies with the requirements in the European Pharmacopoeia (Eur. Ph.) for RNP of FDG and F-18 Sodium Fluoride. (C) 2015 Elsevier Ltd. All rights reserved.",

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AB - In this paper we present the results of an experimental implementation of the method (Jorgensen et al., 2012) for testing the radionuclidic purity (RNP) of F-18 compounds.The overall limitations of the experimental methods and their possible impacts on RNP detectability have been identified. We have developed an GUI application for use as an easy and automated test tool in the production procedure.The test results show that this method fully complies with the requirements in the European Pharmacopoeia (Eur. Ph.) for RNP of FDG and F-18 Sodium Fluoride. (C) 2015 Elsevier Ltd. All rights reserved.

KW - Deadtime correction

KW - F-18

KW - Half life

KW - Radionuclidic purity

KW - Software

KW - Statistical test

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JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Experimental implementation and proof of principle for a radionuclidic purity test solely based on half-life measurement

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Keywords

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