Experimental Airborne Transmission of Porcine Postweaning Multisystemic Wasting Syndrome

C. S. Kristensen; Charlotte Kristiane Hjulsager; K. Vestergaard; Kitt Dupont; Vivi Bille-Hansen; Claes Enøe; Sven Erik Lind Jorsal; P. Bækbo; Lars Erik Larsen

doi:10.1155/2013/534342

Experimental Airborne Transmission of Porcine Postweaning Multisystemic Wasting Syndrome

C. S. Kristensen, Charlotte Kristiane Hjulsager, K. Vestergaard, Kitt Dupont, Vivi Bille-Hansen, Claes Enøe, Sven Erik Lind Jorsal, P. Bækbo, Lars Erik Larsen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The objective of these studies was to investigate if porcine postweaning multisystemic wasting syndrome (PMWS) could be induced in healthy pigs following contact with air from pigs with clinical signs of PMWS. The pigs were housed in different units. Either 31 (study I) or 25 (study II) pigs with clinical symptoms of PMWS from a PMWS-affected herd and 25 healthy pigs from a PMWS-free, but PCV2-positive, herd were housed in unit A. Fifty pigs from a PMWS-free herd were housed in unit B, which were connected by pipes to unit A. In unit C, 30 pigs from a PMWS-free herd were housed as controls. In study II, the pigs in units A and B from the PMWS-free herd developed clinical signs of PMWS 2-3 weeks after arrival. PMWS was confirmed at necropsy and the diseased pigs had increased PCV2 load and increased antibody titers against PCV2 in serum that coincided with the development of clinical signs typical of PMWS. Sequence analysis revealed that the PCV2 isolate belonged to genotype 2b. In conclusion, the present study showed that PMWS can be induced in pigs from a PMWS-free herd by airborne contact with pigs from a PMWS-affected herd.

Original language	English
Journal	Journal of Pathogens
Volume	2013
Pages (from-to)	534342
Number of pages	7
ISSN	2090-3065
DOIs	https://doi.org/10.1155/2013/534342
Publication status	Published - 2013

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This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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title = "Experimental Airborne Transmission of Porcine Postweaning Multisystemic Wasting Syndrome",

abstract = "The objective of these studies was to investigate if porcine postweaning multisystemic wasting syndrome (PMWS) could be induced in healthy pigs following contact with air from pigs with clinical signs of PMWS. The pigs were housed in different units. Either 31 (study I) or 25 (study II) pigs with clinical symptoms of PMWS from a PMWS-affected herd and 25 healthy pigs from a PMWS-free, but PCV2-positive, herd were housed in unit A. Fifty pigs from a PMWS-free herd were housed in unit B, which were connected by pipes to unit A. In unit C, 30 pigs from a PMWS-free herd were housed as controls. In study II, the pigs in units A and B from the PMWS-free herd developed clinical signs of PMWS 2-3 weeks after arrival. PMWS was confirmed at necropsy and the diseased pigs had increased PCV2 load and increased antibody titers against PCV2 in serum that coincided with the development of clinical signs typical of PMWS. Sequence analysis revealed that the PCV2 isolate belonged to genotype 2b. In conclusion, the present study showed that PMWS can be induced in pigs from a PMWS-free herd by airborne contact with pigs from a PMWS-affected herd.",

author = "Kristensen, {C. S.} and Hjulsager, {Charlotte Kristiane} and K. Vestergaard and Kitt Dupont and Vivi Bille-Hansen and Claes En{\o}e and Jorsal, {Sven Erik Lind} and P. B{\ae}kbo and Larsen, {Lars Erik}",

note = "This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2013",

doi = "10.1155/2013/534342",

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volume = "2013",

pages = "534342",

journal = "Journal of Pathogens",

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Experimental Airborne Transmission of Porcine Postweaning Multisystemic Wasting Syndrome. / Kristensen, C. S.; Hjulsager, Charlotte Kristiane; Vestergaard, K.; Dupont, Kitt; Bille-Hansen, Vivi; Enøe, Claes; Jorsal, Sven Erik Lind; Bækbo, P.; Larsen, Lars Erik.

In: Journal of Pathogens, Vol. 2013, 2013, p. 534342.

Research output: Contribution to journal › Journal article › Research › peer-review

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T1 - Experimental Airborne Transmission of Porcine Postweaning Multisystemic Wasting Syndrome

AU - Kristensen, C. S.

AU - Hjulsager, Charlotte Kristiane

AU - Vestergaard, K.

AU - Dupont, Kitt

AU - Bille-Hansen, Vivi

AU - Enøe, Claes

AU - Jorsal, Sven Erik Lind

AU - Bækbo, P.

AU - Larsen, Lars Erik

N1 - This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2013

Y1 - 2013

N2 - The objective of these studies was to investigate if porcine postweaning multisystemic wasting syndrome (PMWS) could be induced in healthy pigs following contact with air from pigs with clinical signs of PMWS. The pigs were housed in different units. Either 31 (study I) or 25 (study II) pigs with clinical symptoms of PMWS from a PMWS-affected herd and 25 healthy pigs from a PMWS-free, but PCV2-positive, herd were housed in unit A. Fifty pigs from a PMWS-free herd were housed in unit B, which were connected by pipes to unit A. In unit C, 30 pigs from a PMWS-free herd were housed as controls. In study II, the pigs in units A and B from the PMWS-free herd developed clinical signs of PMWS 2-3 weeks after arrival. PMWS was confirmed at necropsy and the diseased pigs had increased PCV2 load and increased antibody titers against PCV2 in serum that coincided with the development of clinical signs typical of PMWS. Sequence analysis revealed that the PCV2 isolate belonged to genotype 2b. In conclusion, the present study showed that PMWS can be induced in pigs from a PMWS-free herd by airborne contact with pigs from a PMWS-affected herd.

AB - The objective of these studies was to investigate if porcine postweaning multisystemic wasting syndrome (PMWS) could be induced in healthy pigs following contact with air from pigs with clinical signs of PMWS. The pigs were housed in different units. Either 31 (study I) or 25 (study II) pigs with clinical symptoms of PMWS from a PMWS-affected herd and 25 healthy pigs from a PMWS-free, but PCV2-positive, herd were housed in unit A. Fifty pigs from a PMWS-free herd were housed in unit B, which were connected by pipes to unit A. In unit C, 30 pigs from a PMWS-free herd were housed as controls. In study II, the pigs in units A and B from the PMWS-free herd developed clinical signs of PMWS 2-3 weeks after arrival. PMWS was confirmed at necropsy and the diseased pigs had increased PCV2 load and increased antibody titers against PCV2 in serum that coincided with the development of clinical signs typical of PMWS. Sequence analysis revealed that the PCV2 isolate belonged to genotype 2b. In conclusion, the present study showed that PMWS can be induced in pigs from a PMWS-free herd by airborne contact with pigs from a PMWS-affected herd.

U2 - 10.1155/2013/534342

DO - 10.1155/2013/534342

M3 - Journal article

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VL - 2013

SP - 534342

JO - Journal of Pathogens

JF - Journal of Pathogens

SN - 2090-3065

ER -