Expedient total synthesis of pyrrothine natural products and analogs

Thomas Hjelmgaard, Michael Christian Givskov, John Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review


This paper describes an expedient and straightforward total synthesis of the two pyrrothine natural products holomycin (7 steps, 11% overall) and xenorhabdin I (7 steps, 11% overall) and analogs thereof via a common late-stage intermediate. The pathway proceeds via the pyrrothine hydrochloride intermediate (6 steps, 17% overall) which also gave access to very fast synthesis of analogs as demonstrated by the synthesis of, and (7 steps, 11-12% overall).
Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Issue number2
Pages (from-to)344-348
Publication statusPublished - 2007


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