Excipient for biotherapeutics

Gerhard Winter (Inventor), Andreas Tosstorff (Inventor), Günther Peters (Inventor)

Research output: Patent

13 Downloads (Pure)


The present invention relates to excipients for stabilizing active agents, in particular peptides, polypeptides, nucleic acids, viruses, virus-like particles, proton pump inhibitors and antibiotics. The excipient reduces aggregate and/or particle formation in preparations comprising said agents. The excipient is a diamide of a dicarboxylic acid comprising at least one N-H amido group, at least one unsubstituted or substituted N-hydroxyethylamido group and/or at least one unsubstituted N-hydroxymethylamido group. In particular, the excipient is N,N,N',N'-tetrakis-(2-hydroxyethyl) adipinic acid amide.

Original languageEnglish
IPCC07K 16/ 32 A I
Patent numberWO2021009020
Filing date10/07/2020
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date12/07/2019
Priority numberEP20190186002
Publication statusPublished - 21 Jan 2021


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