TY - JOUR
T1 - Examining the healthy human microbiome concept
AU - Joos, Raphaela
AU - Boucher, Katy
AU - Lavelle, Aonghus
AU - Arumugam, Manimozhiyan
AU - Blaser, Martin J.
AU - Claesson, Marcus J.
AU - Clarke, Gerard
AU - Cotter, Paul D.
AU - De Sordi, Luisa
AU - Dominguez-Bello, Maria G.
AU - Dutilh, Bas E.
AU - Ehrlich, Stanislav D.
AU - Ghosh, Tarini Shankar
AU - Hill, Colin
AU - Junot, Christophe
AU - Lahti, Leo
AU - Lawley, Trevor D.
AU - Licht, Tine R.
AU - Maguin, Emmanuelle
AU - Makhalanyane, Thulani P.
AU - Marchesi, Julian R.
AU - Matthijnssens, Jelle
AU - Raes, Jeroen
AU - Ravel, Jacques
AU - Salonen, Anne
AU - Scanlan, Pauline D.
AU - Shkoporov, Andrey
AU - Stanton, Catherine
AU - Thiele, Ines
AU - Tolstoy, Igor
AU - Walter, Jens
AU - Yang, Bo
AU - Yutin, Natalia
AU - Zhernakova, Alexandra
AU - Zwart, Hub
AU - Human Microbiome Action Consortium
AU - Doré, Joël
AU - Ross, R. Paul
A2 - Arumugam, Manimozhiyan
A2 - Asnicar, Francesco
A2 - Typas, Athanasios
A2 - Betsou, Fay
A2 - Blottière, Hervé
A2 - Bork, Peer
A2 - Boucher, Katy
A2 - Boutron, Isabelle
A2 - Carraturo, Federica
A2 - Claesson, Marcus
A2 - Cordaillat-Simmons, Magali
A2 - Doré, Joël
A2 - Druart, Celine
A2 - Fasano, Alessio
A2 - Godoy, Yolanda
A2 - Haller, Dirk
A2 - Hassani, Zahra
A2 - Hazenbrink, Diënty H. M. J.
A2 - Hill, Colin
A2 - Israelsen, Mads
A2 - Iyappan, Anandhi
A2 - Jarde, Alexander
A2 - Joos, Raphaela
A2 - Kampshoff, Stephan
A2 - Krag, Aleksander
A2 - Kriaa, Aicha
A2 - Lavelle, Aonghus
A2 - Maguin, Emmanuelle
A2 - Metwaly, Amira
A2 - Morozova, Vitalina
A2 - Pinto, Federica
A2 - Pons, Nicolas
A2 - Prost, Pierre Louis
A2 - Ravaud, Philippe
A2 - Rhimi, Moez
A2 - Rodriguez, Julie
A2 - Ross, R. Paul
A2 - Sarati, Arjun
A2 - Schierwagen, Robert
A2 - Segata, Nicola
A2 - Serra, Debora
A2 - Trebicka, Jonel
A2 - Vecchi, Corrado
A2 - Veiga, Patrick
A2 - Zitvogel, Laurence
A2 - Zwart, Hub
A2 - Derosa, Lisa
N1 - Publisher Copyright:
© Springer Nature Limited 2024.
PY - 2025
Y1 - 2025
N2 - Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a ‘healthy’ human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome–health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.
AB - Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a ‘healthy’ human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome–health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.
UR - https://www.nature.com/articles/s41579-024-01145-8
U2 - 10.1038/s41579-024-01107-0
DO - 10.1038/s41579-024-01107-0
M3 - Journal article
C2 - 39443812
AN - SCOPUS:85207670282
SN - 1740-1526
VL - 23
SP - 192
EP - 205
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
ER -