Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients

Rasmus Lykke Marvig, Lea Mette Madsen Sommer, Lars Jelsbak, Søren Molin, Helle Krogh Johansen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality connected with this disease. The ability of P. aeruginosa to establish chronic infections in CF patients is suggested to be due to the large genetic repertoire of P. aeruginosa and its ability to genetically adapt to the host environment. Here, we review the recent work that has applied whole-genome sequencing to understand P. aeruginosa population genomics, within-host microevolution and diversity, mutational mechanisms, genetic adaptation and transmission events. Finally, we summarize the advances in relation to medical applications and laboratory evolution experiments.
Original languageEnglish
JournalFuture Microbiology
Volume10
Issue number4
Pages (from-to)599-611
Number of pages13
ISSN1746-0913
DOIs
Publication statusPublished - 2015

Cite this

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title = "Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients",
abstract = "The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality connected with this disease. The ability of P. aeruginosa to establish chronic infections in CF patients is suggested to be due to the large genetic repertoire of P. aeruginosa and its ability to genetically adapt to the host environment. Here, we review the recent work that has applied whole-genome sequencing to understand P. aeruginosa population genomics, within-host microevolution and diversity, mutational mechanisms, genetic adaptation and transmission events. Finally, we summarize the advances in relation to medical applications and laboratory evolution experiments.",
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Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients. / Marvig, Rasmus Lykke; Madsen Sommer, Lea Mette; Jelsbak, Lars; Molin, Søren; Johansen, Helle Krogh.

In: Future Microbiology, Vol. 10, No. 4, 2015, p. 599-611.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients

AU - Marvig, Rasmus Lykke

AU - Madsen Sommer, Lea Mette

AU - Jelsbak, Lars

AU - Molin, Søren

AU - Johansen, Helle Krogh

PY - 2015

Y1 - 2015

N2 - The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality connected with this disease. The ability of P. aeruginosa to establish chronic infections in CF patients is suggested to be due to the large genetic repertoire of P. aeruginosa and its ability to genetically adapt to the host environment. Here, we review the recent work that has applied whole-genome sequencing to understand P. aeruginosa population genomics, within-host microevolution and diversity, mutational mechanisms, genetic adaptation and transmission events. Finally, we summarize the advances in relation to medical applications and laboratory evolution experiments.

AB - The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality connected with this disease. The ability of P. aeruginosa to establish chronic infections in CF patients is suggested to be due to the large genetic repertoire of P. aeruginosa and its ability to genetically adapt to the host environment. Here, we review the recent work that has applied whole-genome sequencing to understand P. aeruginosa population genomics, within-host microevolution and diversity, mutational mechanisms, genetic adaptation and transmission events. Finally, we summarize the advances in relation to medical applications and laboratory evolution experiments.

U2 - 10.2217/FMB.15.3

DO - 10.2217/FMB.15.3

M3 - Journal article

VL - 10

SP - 599

EP - 611

JO - Future Microbiology

JF - Future Microbiology

SN - 1746-0913

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ER -