Evolution of complex structures: minicollagens shape the cnidarian nematocyst

Charles N. David, Suat Oezbek, Patrizia Adamczyk, Sebastian Meier, Barbara Pauly, Jarrod Chapman, Jung Shan Hwang, Takashi Gojobori, Thomas W. Holstein

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The generation of biological complexity by the acquisition of novel modular units is an emerging concept in evolutionary dynamics. Here, we review the coordinate evolution of cnidarian nematocysts, secretory organelles used for capture of prey, and of minicollagens, proteins constituting the nematocyst capsule. Within the Cnidaria there is an increase in nematocyst complexity from Anthozoa to Medusozoa and a parallel increase in the number and complexity of minicollagen proteins. This complexity is primarily manifest in a diversification of N- and C-terminal cysteine-rich domains (CRDs) involved in minicollagen polymerization. We hypothesize that novel CRD motifs alter minicollagen networks, leading to novel capsule structures and nematocyst types.
Original languageEnglish
JournalTrends in Genetics
Volume24
Issue number9
Pages (from-to)431-438
ISSN0168-9525
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • DYNAMICS
  • Amino Acid Sequence
  • Animal Structures
  • Animals
  • Biological Evolution
  • Cnidaria
  • Collagen
  • Genome
  • Molecular Sequence Data
  • 9007-34-5 Collagen
  • collagen
  • amino terminal sequence
  • Anthozoa
  • article
  • carboxy terminal sequence
  • coelenterate
  • controlled study
  • gene expression
  • nonhuman
  • priority journal
  • Evolution
  • GENETICS
  • HYDRA NEMATOCYSTS
  • EXTRUSIVE ORGANELLES
  • MINI-COLLAGENS
  • DISCHARGE
  • PROTEIN
  • ORIGIN
  • WALL
  • CAPSULES
  • HYDROZOA
  • DOMAINS
  • biological complexity
  • evolutionary dynamics
  • nematocyst complexity
  • prey capture
  • Invertebrata Animalia (Animals, Invertebrates) - Cnidaria [41000] Anthozoa higher_taxa cnidarian common Medusozoa higher_taxa
  • cysteine-rich domains
  • minicollagen polymerization
  • proteins
  • 01500, Evolution
  • 02502, Cytology - General
  • 02506, Cytology - Animal
  • 10060, Biochemistry studies - General
  • 10064, Biochemistry studies - Proteins, peptides and amino acids
  • 64008, Invertebrata: comparative, experimental morphology, physiology and pathology - Cnidaria
  • nematocyst
  • secretory organelles
  • Biochemistry and Molecular Biophysics
  • Cell Biology
  • Evolution and Adaptation

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