Evidence of recombination among early-vaccination era measles virus strains

Mikkel H Schierup; Carl H. Mordhorst; Claude P. Muller; Laurids Siig Christensen

doi:10.1186/1471-2148-5-52

Evidence of recombination among early-vaccination era measles virus strains

Mikkel H Schierup, Carl H. Mordhorst, Claude P. Muller, Laurids Siig Christensen

Research output: Contribution to journal › Journal article › Research › peer-review

171 Downloads (Pure)

Abstract

Background: The advent of live-attenuated vaccines against measles virus during the 1960' ies changed the circulation dynamics of the virus. Earlier the virus was indigenous to countries worldwide, but now it is mediated by a limited number of evolutionary lineages causing sporadic outbreaks/ epidemics of measles or circulating in geographically restricted endemic areas of Africa, Asia and Europe. We expect that the evolutionary dynamics of measles virus has changed from a situation where a variety of genomic variants co-circulates in an epidemic with relatively high probabilities of co-infection of the individual to a situation where a co-infection with strains from evolutionary different lineages is unlikely.

Original language	English
Journal	BMC Evolutionary Biology
Volume	5
Pages (from-to)	52
ISSN	1471-2148
DOIs	https://doi.org/10.1186/1471-2148-5-52
Publication status	Published - 2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/1471-2148-5-52

1471-2148-5-52Final published version, 541 KB

OpenUrl availability

Full text

Cite this

@article{9da891c418bc421d8937fc1174e16ac5,

title = "Evidence of recombination among early-vaccination era measles virus strains",

abstract = "Background: The advent of live-attenuated vaccines against measles virus during the 1960' ies changed the circulation dynamics of the virus. Earlier the virus was indigenous to countries worldwide, but now it is mediated by a limited number of evolutionary lineages causing sporadic outbreaks/ epidemics of measles or circulating in geographically restricted endemic areas of Africa, Asia and Europe. We expect that the evolutionary dynamics of measles virus has changed from a situation where a variety of genomic variants co-circulates in an epidemic with relatively high probabilities of co-infection of the individual to a situation where a co-infection with strains from evolutionary different lineages is unlikely.",

author = "Schierup, {Mikkel H} and Mordhorst, {Carl H.} and Muller, {Claude P.} and Christensen, {Laurids Siig}",

year = "2005",

doi = "10.1186/1471-2148-5-52",

language = "English",

volume = "5",

pages = "52",

journal = "BMC Evolutionary Biology",

issn = "1471-2148",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Evidence of recombination among early-vaccination era measles virus strains

AU - Schierup, Mikkel H

AU - Mordhorst, Carl H.

AU - Muller, Claude P.

AU - Christensen, Laurids Siig

PY - 2005

Y1 - 2005

N2 - Background: The advent of live-attenuated vaccines against measles virus during the 1960' ies changed the circulation dynamics of the virus. Earlier the virus was indigenous to countries worldwide, but now it is mediated by a limited number of evolutionary lineages causing sporadic outbreaks/ epidemics of measles or circulating in geographically restricted endemic areas of Africa, Asia and Europe. We expect that the evolutionary dynamics of measles virus has changed from a situation where a variety of genomic variants co-circulates in an epidemic with relatively high probabilities of co-infection of the individual to a situation where a co-infection with strains from evolutionary different lineages is unlikely.

AB - Background: The advent of live-attenuated vaccines against measles virus during the 1960' ies changed the circulation dynamics of the virus. Earlier the virus was indigenous to countries worldwide, but now it is mediated by a limited number of evolutionary lineages causing sporadic outbreaks/ epidemics of measles or circulating in geographically restricted endemic areas of Africa, Asia and Europe. We expect that the evolutionary dynamics of measles virus has changed from a situation where a variety of genomic variants co-circulates in an epidemic with relatively high probabilities of co-infection of the individual to a situation where a co-infection with strains from evolutionary different lineages is unlikely.

U2 - 10.1186/1471-2148-5-52

DO - 10.1186/1471-2148-5-52

M3 - Journal article

SN - 1471-2148

VL - 5

SP - 52

JO - BMC Evolutionary Biology

JF - BMC Evolutionary Biology

ER -

Evidence of recombination among early-vaccination era measles virus strains

Abstract

UN SDGs

Access to Document

OpenUrl availability

Fingerprint

Cite this