Evidence of recombination among early-vaccination era measles virus strains

Mikkel H Schierup, Carl H. Mordhorst, Claude P. Muller, Laurids Siig Christensen

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Abstract

Background: The advent of live-attenuated vaccines against measles virus during the 1960' ies changed the circulation dynamics of the virus. Earlier the virus was indigenous to countries worldwide, but now it is mediated by a limited number of evolutionary lineages causing sporadic outbreaks/ epidemics of measles or circulating in geographically restricted endemic areas of Africa, Asia and Europe. We expect that the evolutionary dynamics of measles virus has changed from a situation where a variety of genomic variants co-circulates in an epidemic with relatively high probabilities of co-infection of the individual to a situation where a co-infection with strains from evolutionary different lineages is unlikely.
Original languageEnglish
JournalBMC Evolutionary Biology
Volume5
Pages (from-to)52
ISSN1471-2148
DOIs
Publication statusPublished - 2005
Externally publishedYes

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