Evidence of No Association Between Human Papillomavirus and Breast Cancer

Sara  Bønløkke; Jan Blaakær; Torben Steiniche; Estrid Høgdall; Steffen Grann Jensen; Anne  Hammer; Eva Balslev; Mikael Lenz Strube; Helle Knakkergaard; Suzan Lenz

doi:10.3389/fonc.2018.00209

Evidence of No Association Between Human Papillomavirus and Breast Cancer

Sara Bønløkke^*, Jan Blaakær, Torben Steiniche, Estrid Høgdall, Steffen Grann Jensen, Anne Hammer, Eva Balslev, Mikael Lenz Strube, Helle Knakkergaard, Suzan Lenz

^*Corresponding author for this work

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Abstract

Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without.
Methods: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF₁₀ PCR-DEIA-LiPA₂₅ and an in-house semi-Q-PCR assay.
Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%.
Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

Original language	English
Article number	209
Journal	Frontiers in Oncology
Volume	8
DOIs	https://doi.org/10.3389/fonc.2018.00209
Publication status	Published - 2018

Bibliographical note

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Keywords

Breast cancer
HPV
Cervical cancer
Polymerase chain reaction
Denmark
Pathology
Human papillomavirus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Evidence of No Association Between Human Papillomavirus and Breast Cancer",

abstract = "Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without.Methods: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF10 PCR-DEIA-LiPA25 and an in-house semi-Q-PCR assay.Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%.Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.",

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author = "Sara B{\o}nl{\o}kke and Jan Blaak{\ae}r and Torben Steiniche and Estrid H{\o}gdall and Jensen, {Steffen Grann} and Anne Hammer and Eva Balslev and Strube, {Mikael Lenz} and Helle Knakkergaard and Suzan Lenz",

note = "This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.",

year = "2018",

doi = "10.3389/fonc.2018.00209",

language = "English",

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journal = "Frontiers in Oncology",

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TY - JOUR

T1 - Evidence of No Association Between Human Papillomavirus and Breast Cancer

AU - Bønløkke, Sara

AU - Blaakær, Jan

AU - Steiniche, Torben

AU - Høgdall, Estrid

AU - Jensen, Steffen Grann

AU - Hammer, Anne

AU - Balslev, Eva

AU - Strube, Mikael Lenz

AU - Knakkergaard, Helle

AU - Lenz, Suzan

N1 - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PY - 2018

Y1 - 2018

N2 - Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without.Methods: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF10 PCR-DEIA-LiPA25 and an in-house semi-Q-PCR assay.Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%.Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

AB - Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without.Methods: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF10 PCR-DEIA-LiPA25 and an in-house semi-Q-PCR assay.Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%.Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

KW - Breast cancer

KW - HPV

KW - Cervical cancer

KW - Polymerase chain reaction

KW - Denmark

KW - Pathology

KW - Human papillomavirus

U2 - 10.3389/fonc.2018.00209

DO - 10.3389/fonc.2018.00209

M3 - Journal article

C2 - 29938198

SN - 2234-943X

VL - 8

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 209

ER -

Evidence of No Association Between Human Papillomavirus and Breast Cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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