TY - JOUR
T1 - Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy
AU - Samaeifar, Fatemeh
AU - Casci Ceccacci, Andrea
AU - Bose-Goswami, Sanjukta
AU - Nielsen, Line Hagner
AU - Afifi, Ahmad
AU - Zor, Kinga
AU - Boisen, Anja
PY - 2019
Y1 - 2019
N2 - Assessing physical stability of drugs is important both in the development as well as in the production phase in the pharmaceutical industry. We used nanomechanical infrared (NAM-IR) spectroscopy based on photothermal response of a nanomechanical resonator, to investigate the solid state forms of tadalafil (TAD), under various storage conditions in sub-micron thin films. The amorphous TAD was stable, when kept at normal storage conditions of 24 °C, 45% relative humidity (RH) and shielded from light, however, it crystallized after four days when it was at stress storage conditions (40 °C, 70% RH, and direct sunlight). Additionally, we found that the signals recorded with NAM-IR were comparable with the attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and that NAM-IR proved to be a suitable and time efficient method when evaluating TAD in sub 500 nm layers.
AB - Assessing physical stability of drugs is important both in the development as well as in the production phase in the pharmaceutical industry. We used nanomechanical infrared (NAM-IR) spectroscopy based on photothermal response of a nanomechanical resonator, to investigate the solid state forms of tadalafil (TAD), under various storage conditions in sub-micron thin films. The amorphous TAD was stable, when kept at normal storage conditions of 24 °C, 45% relative humidity (RH) and shielded from light, however, it crystallized after four days when it was at stress storage conditions (40 °C, 70% RH, and direct sunlight). Additionally, we found that the signals recorded with NAM-IR were comparable with the attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and that NAM-IR proved to be a suitable and time efficient method when evaluating TAD in sub 500 nm layers.
KW - Amorphous
KW - Crystalline
KW - NAM-IR
KW - Resonator
KW - Tadalafil
U2 - 10.1016/j.ijpharm.2019.05.010
DO - 10.1016/j.ijpharm.2019.05.010
M3 - Journal article
C2 - 31077764
SN - 0378-5173
VL - 565
SP - 227
EP - 232
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
ER -