Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy

Fatemeh Samaeifar, Andrea Casci Ceccacci, Sanjukta Bose-Goswami, Line Hagner Nielsen, Ahmad Afifi, Kinga Zor*, Anja Boisen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Assessing physical stability of drugs is important both in the development as well as in the production phase in the pharmaceutical industry. We used nanomechanical infrared (NAM-IR) spectroscopy based on photothermal response of a nanomechanical resonator, to investigate the solid state forms of tadalafil (TAD), under various storage conditions in sub-micron thin films. The amorphous TAD was stable, when kept at normal storage conditions of 24 °C, 45% relative humidity (RH) and shielded from light, however, it crystallized after four days when it was at stress storage conditions (40 °C, 70% RH, and direct sunlight). Additionally, we found that the signals recorded with NAM-IR were comparable with the attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and that NAM-IR proved to be a suitable and time efficient method when evaluating TAD in sub 500 nm layers.
Original languageEnglish
JournalInternational Journal of Pharmaceutics
Volume565
Pages (from-to)227-232
ISSN0378-5173
DOIs
Publication statusPublished - 2019

Keywords

  • Amorphous
  • Crystalline
  • NAM-IR
  • Resonator
  • Tadalafil

Cite this

@article{45ac07819bd44e10a1b765627b8f5bd9,
title = "Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy",
abstract = "Assessing physical stability of drugs is important both in the development as well as in the production phase in the pharmaceutical industry. We used nanomechanical infrared (NAM-IR) spectroscopy based on photothermal response of a nanomechanical resonator, to investigate the solid state forms of tadalafil (TAD), under various storage conditions in sub-micron thin films. The amorphous TAD was stable, when kept at normal storage conditions of 24 °C, 45{\%} relative humidity (RH) and shielded from light, however, it crystallized after four days when it was at stress storage conditions (40 °C, 70{\%} RH, and direct sunlight). Additionally, we found that the signals recorded with NAM-IR were comparable with the attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and that NAM-IR proved to be a suitable and time efficient method when evaluating TAD in sub 500 nm layers.",
keywords = "Amorphous, Crystalline, NAM-IR, Resonator, Tadalafil",
author = "Fatemeh Samaeifar and {Casci Ceccacci}, Andrea and Sanjukta Bose-Goswami and Nielsen, {Line Hagner} and Ahmad Afifi and Kinga Zor and Anja Boisen",
year = "2019",
doi = "10.1016/j.ijpharm.2019.05.010",
language = "English",
volume = "565",
pages = "227--232",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy. / Samaeifar, Fatemeh; Casci Ceccacci, Andrea; Bose-Goswami, Sanjukta; Nielsen, Line Hagner; Afifi, Ahmad; Zor, Kinga; Boisen, Anja.

In: International Journal of Pharmaceutics, Vol. 565, 2019, p. 227-232.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy

AU - Samaeifar, Fatemeh

AU - Casci Ceccacci, Andrea

AU - Bose-Goswami, Sanjukta

AU - Nielsen, Line Hagner

AU - Afifi, Ahmad

AU - Zor, Kinga

AU - Boisen, Anja

PY - 2019

Y1 - 2019

N2 - Assessing physical stability of drugs is important both in the development as well as in the production phase in the pharmaceutical industry. We used nanomechanical infrared (NAM-IR) spectroscopy based on photothermal response of a nanomechanical resonator, to investigate the solid state forms of tadalafil (TAD), under various storage conditions in sub-micron thin films. The amorphous TAD was stable, when kept at normal storage conditions of 24 °C, 45% relative humidity (RH) and shielded from light, however, it crystallized after four days when it was at stress storage conditions (40 °C, 70% RH, and direct sunlight). Additionally, we found that the signals recorded with NAM-IR were comparable with the attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and that NAM-IR proved to be a suitable and time efficient method when evaluating TAD in sub 500 nm layers.

AB - Assessing physical stability of drugs is important both in the development as well as in the production phase in the pharmaceutical industry. We used nanomechanical infrared (NAM-IR) spectroscopy based on photothermal response of a nanomechanical resonator, to investigate the solid state forms of tadalafil (TAD), under various storage conditions in sub-micron thin films. The amorphous TAD was stable, when kept at normal storage conditions of 24 °C, 45% relative humidity (RH) and shielded from light, however, it crystallized after four days when it was at stress storage conditions (40 °C, 70% RH, and direct sunlight). Additionally, we found that the signals recorded with NAM-IR were comparable with the attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and that NAM-IR proved to be a suitable and time efficient method when evaluating TAD in sub 500 nm layers.

KW - Amorphous

KW - Crystalline

KW - NAM-IR

KW - Resonator

KW - Tadalafil

U2 - 10.1016/j.ijpharm.2019.05.010

DO - 10.1016/j.ijpharm.2019.05.010

M3 - Journal article

C2 - 31077764

VL - 565

SP - 227

EP - 232

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

ER -