Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

Kirstin Friederike Heise; Nick Kortzorg; Guilherme Bicalho Saturnino; Hakuei Fujiyama; Koen Cuypers; Axel Thielscher; Stephan P. Swinnen

doi:10.1016/j.brs.2016.04.009

Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

Kirstin Friederike Heise, Nick Kortzorg, Guilherme Bicalho Saturnino, Hakuei Fujiyama, Koen Cuypers, Axel Thielscher, Stephan P. Swinnen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Objective: To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation. Methods: In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation). Results: Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage. Conclusions: In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.

Original language	English
Journal	Brain Stimulation
Volume	9
Issue number	5
Pages (from-to)	700–704
Number of pages	5
ISSN	1935-861X
DOIs	https://doi.org/10.1016/j.brs.2016.04.009
Publication status	Published - 2016

Keywords

Neurology (clinical)
Neuroscience (all)
Biophysics
Beta frequency
Corticospinal excitability
High-density electrode montage
Neurosensory effects
Transcranial alternating current stimulation

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title = "Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas",

abstract = "Objective: To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation. Methods: In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation). Results: Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage. Conclusions: In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.",

keywords = "Neurology (clinical), Neuroscience (all), Biophysics, Beta frequency, Corticospinal excitability, High-density electrode montage, Neurosensory effects, Transcranial alternating current stimulation",

author = "Heise, {Kirstin Friederike} and Nick Kortzorg and Saturnino, {Guilherme Bicalho} and Hakuei Fujiyama and Koen Cuypers and Axel Thielscher and Swinnen, {Stephan P.}",

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T1 - Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

AU - Heise, Kirstin Friederike

AU - Kortzorg, Nick

AU - Saturnino, Guilherme Bicalho

AU - Fujiyama, Hakuei

AU - Cuypers, Koen

AU - Thielscher, Axel

AU - Swinnen, Stephan P.

PY - 2016

Y1 - 2016

N2 - Objective: To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation. Methods: In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation). Results: Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage. Conclusions: In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.

AB - Objective: To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation. Methods: In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation). Results: Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage. Conclusions: In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.

KW - Neurology (clinical)

KW - Neuroscience (all)

KW - Biophysics

KW - Beta frequency

KW - Corticospinal excitability

KW - High-density electrode montage

KW - Neurosensory effects

KW - Transcranial alternating current stimulation

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DO - 10.1016/j.brs.2016.04.009

M3 - Journal article

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SN - 1935-861X

VL - 9

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JO - Brain Stimulation

JF - Brain Stimulation

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ER -

Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

Abstract

Keywords

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