Eukaryotic interference with homoserine lactone mediated procaryotic signalling.

  • Michael Christian Givskov
  • , Rocky de Nys
  • , Lone Gram
  • , Ria Maximilien
  • , Leo Eberl
  • , Søren Molin
  • , Peter Steinberg
  • , Staffan Kjelleberg

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Acylated homoserine lactones (AHLs) plays a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.
Original languageEnglish
JournalJournal of Bacteriology
Volume178
Issue number22
Pages (from-to)6618-6622
ISSN0021-9193
Publication statusPublished - 1996

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