Eukaryotic interference with homoserine lactone mediated procaryotic signalling.

Michael Christian Givskov, Rocky de Nys, Lone Gram, Ria Maximilien, Leo Eberl, Søren Molin, Peter Steinberg, Staffan Kjelleberg

Research output: Contribution to journalJournal articleResearchpeer-review


Acylated homoserine lactones (AHLs) plays a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.
Original languageEnglish
JournalJournal of Bacteriology
Issue number22
Pages (from-to)6618-6622
Publication statusPublished - 1996


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