Estimation of Plaque Contents With Multi-Angle 3D Compound Imaging

Jens E. Wilhjelm, Marie Louise Grønholdt, Steen Tofthøj Rasmussen, Kjeld Martinsen, Henrik Sillesen

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This investigation exploits the potential of using multiple insonification angles in characterizing plaques in the carotid artery. Specifically, previous work has shown that certain plaque materials such as lipid exhibit a low degree of angle-dependence in the received echo signal while the signal varies much more with angle for fibrous tissues. An experimental multi-angle 3D pulse-echo recording system has been established with a 10 MHz focused single element transducer mounted on a high precision rotational device. The received signal was processed in order to match axial resolution size to lateral resolution size (1.4 mm @ -3 dB) to obtain an omnidirectional range cell. After scanning, the plaques underwent histological analysis in order to estimate the amount of calcification, fibrous tissues, lipid, blood and thrombus. So far, 13 plaques surgically removed during carotid endarterectomy have been scanned in 3D from five different angles. Based on the angle-dependence of the signal energy for each range cell, six features could be extracted and correlated to the histological results. From the limited amount of data presented here, correlation was found between one feature and the content of fibrous tissues. The preliminary results indicate that the method has good potential for characterization of plaque.
Original languageEnglish
Title of host publicationProceedings of the IEEE International Ultrasonics Symposium
Publication date1996
ISBN (Print)0-7803-3615-1
Publication statusPublished - 1996
Event1996 IEEE Ultrasonics Symposium - San Antonio, TX, United States
Duration: 3 Nov 19966 Nov 1996


Conference1996 IEEE Ultrasonics Symposium
CountryUnited States
CitySan Antonio, TX
Internet address

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Wilhjelm, J. E., Grønholdt, M. L., Rasmussen, S. T., Martinsen, K., & Sillesen, H. (1996). Estimation of Plaque Contents With Multi-Angle 3D Compound Imaging. In Proceedings of the IEEE International Ultrasonics Symposium (pp. 1077-1080). IEEE.