Estimation of Plaque Contents With Multi-Angle 3D Compound Imaging

Jens E. Wilhjelm, Marie Louise Grønholdt, Steen Tofthøj Rasmussen, Kjeld Martinsen, Henrik Sillesen

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Abstract

This investigation exploits the potential of using multiple insonification angles in characterizing plaques in the carotid artery. Specifically, previous work has shown that certain plaque materials such as lipid exhibit a low degree of angle-dependence in the received echo signal while the signal varies much more with angle for fibrous tissues. An experimental multi-angle 3D pulse-echo recording system has been established with a 10 MHz focused single element transducer mounted on a high precision rotational device. The received signal was processed in order to match axial resolution size to lateral resolution size (1.4 mm @ -3 dB) to obtain an omnidirectional range cell. After scanning, the plaques underwent histological analysis in order to estimate the amount of calcification, fibrous tissues, lipid, blood and thrombus. So far, 13 plaques surgically removed during carotid endarterectomy have been scanned in 3D from five different angles. Based on the angle-dependence of the signal energy for each range cell, six features could be extracted and correlated to the histological results. From the limited amount of data presented here, correlation was found between one feature and the content of fibrous tissues. The preliminary results indicate that the method has good potential for characterization of plaque.
Original languageEnglish
Title of host publicationProceedings of the IEEE International Ultrasonics Symposium
PublisherIEEE
Publication date1996
Pages1077-1080
ISBN (Print)0-7803-3615-1
DOIs
Publication statusPublished - 1996
Event1996 IEEE Ultrasonics Symposium - San Antonio, TX, United States
Duration: 3 Nov 19966 Nov 1996
http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=4446

Conference

Conference1996 IEEE Ultrasonics Symposium
CountryUnited States
CitySan Antonio, TX
Period03/11/199606/11/1996
Internet address

Bibliographical note

Copyright: 1996 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE

Cite this

Wilhjelm, J. E., Grønholdt, M. L., Rasmussen, S. T., Martinsen, K., & Sillesen, H. (1996). Estimation of Plaque Contents With Multi-Angle 3D Compound Imaging. In Proceedings of the IEEE International Ultrasonics Symposium (pp. 1077-1080). IEEE. https://doi.org/10.1109/ULTSYM.1996.584178