Estimation of Chromatographic Columns Performances using Computer Tomography and CFD Simulations

Irma Schmidt, Florian Lottes, Mirjana Minceva, Wolfgang Arlt, Erling Halfdan Stenby

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The flow inside a chromatographic column depends decisively on the packed bed inside. Non‐destructive X‐ray computed tomography (CT) was applied as a novel measurement technique to visualize the distribution of velocity and axial dispersion coefficients in preparative scale columns. The results show, that spherical particles seem to be more efficient than irregular ones in terms of HETP, which has to be partly a result of the more homogeneous flow profile they induce. The prediction of column performance in dependence of the structure of the packed bed was simulated by CFD (Computational Fluid Dynamics), using a model which besides the hydrodynamics parameters attained by CT also includes adsorption isotherms and mass transfer parameters. The results of the CFD simulation shall help to establish rules for selecting the right adsorption material for a given separation task in advance.
Original languageEnglish
JournalChemie-Ingenieur-Technik
Volume83
Issue number1‐2
Pages (from-to)130-142
ISSN0009-286X
DOIs
Publication statusPublished - 2011

Keywords

  • Computer tomography
  • Chromatography
  • CFD
  • Column

Fingerprint Dive into the research topics of 'Estimation of Chromatographic Columns Performances using Computer Tomography and CFD Simulations'. Together they form a unique fingerprint.

Cite this