Estimating the Intensity and Anisotropy of Tumor Treating Fields Jsing Singular Value Decomposition. Towards a More Comprehensive Estimation of Anti-tumor Efficacy

Anders R. Korshoej*, Axel Thielscher

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

Tumor treating fields (TTFields) is an anticancer treatment that inhibits tumor growth with alternating electrical fields. Finite element (FE) methods have been used to estimate the TTFields intensity as a measure of treatment 'dose'. However, TTFields efficacy also depends on field direction and exposure time. Here we propose a new FE based approach, which uses all these parameters to quantify the average field intensity and the amount of unwanted directional field correlation (fractional anisotropy, FA). The method is based on principal component decomposition of the sequential TTFields over one duty cycle. Using a realistic head model of a glioblastoma patient, we observed significant unwanted FA in many regions of the brain, which may potentially affect therapeutic efficacy. FA varied between different array layouts and indicated a different order of array performance than predicted from the field intensity. Tumor resection nullified differences in field distributions between layouts and increased FA considerably. Our results question the rationale for the use of macroscopically orthogonal array layouts to reduce field correlation and rather indicate that arrays should be placed to maximize pathology coverage and field intensity. The proposed calculation framework has several potential applications, incl. improved treatment planning, technology development, and accurate prognostication models. Future studies are required to validate the method.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Volume2018-July
PublisherIEEE
Publication date26 Oct 2018
Pages4897-4900
Article number8513440
ISBN (Electronic)9781538636466
DOIs
Publication statusPublished - 26 Oct 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States
Duration: 18 Jul 201821 Jul 2018

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
CountryUnited States
CityHonolulu
Period18/07/201821/07/2018

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