Estimating the burden of disease of exposure to chemical contaminants in food in Denmark

Research output: Contribution to journalConference articleResearchpeer-review

Abstract

Background
Recent global estimates have shown that dietary exposure to chemical contaminants cause over 56,000 deaths and 9 million healthy life years lost each year. However, the contribution of causative agents varies greatly between world regions and countries due to local food consumption and contamination. To prioritize public health interventions to reduce disease burden, national-level risk ranking evidence is needed. The overall aims of this project are to estimate the burden of disease (BoD) of selected chemical hazards in foods consumed in Denmark, and to identify the relative contribution of foods.

Methods
We identified chemicals on the basis of their presumed public health impact. The final list of chemicals was defined in agreement with the Danish Veterinary and Food Administration, and included: methylmercury, inorganic arsenic, cadmium, acrylamide, dioxin/dioxin-like PCBs and lead. We estimated BoD in terms of disability adjusted life years (DALY) in a model combining exposure assessment with dose response models to derive probabilities of health effects, taking an incidence-based approach. Data were collected from the Danish National Survey of Diet and Physical Activity, food monitoring, literature, and national statistics.

Results
We estimated that methylmercury, inorganic arsenic, cadmium and acrylamide lead to a BoD of 514 DALY (95% uncertainty interval: 185, 990) in 2016 (preliminary results). Estimates for lead and dioxin/dioxin-like PCBs are pending. Methylmercury exposure from fish was the greatest contributor to overall burden (478 DALY), and acrylamide from potato products the second (30 DALY). The health outcomes leading to highest burden were intellectual disability and cancer.

Conclusions
Our estimates will assist public health managers identifying the chemical contaminants in foods with the highest impact on public health in Denmark. Future research should focus on estimating the effect of mitigation strategies on the disease burden.
Original languageEnglish
JournalEuropean Journal of Public Health
Volume29
Issue numberSuppl. 4
Pages (from-to)490-490
ISSN1101-1262
DOIs
Publication statusPublished - 2019
Event12th European Public Health Conference Building bridges for solidarity and public health - Marseille, France
Duration: 20 Nov 201923 Nov 2019
Conference number: 12

Conference

Conference12th European Public Health Conference Building bridges for solidarity and public health
Number12
CountryFrance
CityMarseille
Period20/11/201923/11/2019

Cite this

@inproceedings{5b38fb80e17e4f328c5bea36b18a23e7,
title = "Estimating the burden of disease of exposure to chemical contaminants in food in Denmark",
abstract = "BackgroundRecent global estimates have shown that dietary exposure to chemical contaminants cause over 56,000 deaths and 9 million healthy life years lost each year. However, the contribution of causative agents varies greatly between world regions and countries due to local food consumption and contamination. To prioritize public health interventions to reduce disease burden, national-level risk ranking evidence is needed. The overall aims of this project are to estimate the burden of disease (BoD) of selected chemical hazards in foods consumed in Denmark, and to identify the relative contribution of foods.MethodsWe identified chemicals on the basis of their presumed public health impact. The final list of chemicals was defined in agreement with the Danish Veterinary and Food Administration, and included: methylmercury, inorganic arsenic, cadmium, acrylamide, dioxin/dioxin-like PCBs and lead. We estimated BoD in terms of disability adjusted life years (DALY) in a model combining exposure assessment with dose response models to derive probabilities of health effects, taking an incidence-based approach. Data were collected from the Danish National Survey of Diet and Physical Activity, food monitoring, literature, and national statistics.ResultsWe estimated that methylmercury, inorganic arsenic, cadmium and acrylamide lead to a BoD of 514 DALY (95{\%} uncertainty interval: 185, 990) in 2016 (preliminary results). Estimates for lead and dioxin/dioxin-like PCBs are pending. Methylmercury exposure from fish was the greatest contributor to overall burden (478 DALY), and acrylamide from potato products the second (30 DALY). The health outcomes leading to highest burden were intellectual disability and cancer.ConclusionsOur estimates will assist public health managers identifying the chemical contaminants in foods with the highest impact on public health in Denmark. Future research should focus on estimating the effect of mitigation strategies on the disease burden.",
author = "Jakobsen, {Lea Sletting} and Thomsen, {Sofie Theresa} and Pires, {Sara Monteiro}",
year = "2019",
doi = "10.1093/eurpub/ckz186.288",
language = "English",
volume = "29",
pages = "490--490",
journal = "European Journal of Public Health",
issn = "1101-1262",
publisher = "Oxford University Press",
number = "Suppl. 4",

}

Estimating the burden of disease of exposure to chemical contaminants in food in Denmark. / Jakobsen, Lea Sletting; Thomsen, Sofie Theresa; Pires, Sara Monteiro.

In: European Journal of Public Health, Vol. 29, No. Suppl. 4, 2019, p. 490-490.

Research output: Contribution to journalConference articleResearchpeer-review

TY - GEN

T1 - Estimating the burden of disease of exposure to chemical contaminants in food in Denmark

AU - Jakobsen, Lea Sletting

AU - Thomsen, Sofie Theresa

AU - Pires, Sara Monteiro

PY - 2019

Y1 - 2019

N2 - BackgroundRecent global estimates have shown that dietary exposure to chemical contaminants cause over 56,000 deaths and 9 million healthy life years lost each year. However, the contribution of causative agents varies greatly between world regions and countries due to local food consumption and contamination. To prioritize public health interventions to reduce disease burden, national-level risk ranking evidence is needed. The overall aims of this project are to estimate the burden of disease (BoD) of selected chemical hazards in foods consumed in Denmark, and to identify the relative contribution of foods.MethodsWe identified chemicals on the basis of their presumed public health impact. The final list of chemicals was defined in agreement with the Danish Veterinary and Food Administration, and included: methylmercury, inorganic arsenic, cadmium, acrylamide, dioxin/dioxin-like PCBs and lead. We estimated BoD in terms of disability adjusted life years (DALY) in a model combining exposure assessment with dose response models to derive probabilities of health effects, taking an incidence-based approach. Data were collected from the Danish National Survey of Diet and Physical Activity, food monitoring, literature, and national statistics.ResultsWe estimated that methylmercury, inorganic arsenic, cadmium and acrylamide lead to a BoD of 514 DALY (95% uncertainty interval: 185, 990) in 2016 (preliminary results). Estimates for lead and dioxin/dioxin-like PCBs are pending. Methylmercury exposure from fish was the greatest contributor to overall burden (478 DALY), and acrylamide from potato products the second (30 DALY). The health outcomes leading to highest burden were intellectual disability and cancer.ConclusionsOur estimates will assist public health managers identifying the chemical contaminants in foods with the highest impact on public health in Denmark. Future research should focus on estimating the effect of mitigation strategies on the disease burden.

AB - BackgroundRecent global estimates have shown that dietary exposure to chemical contaminants cause over 56,000 deaths and 9 million healthy life years lost each year. However, the contribution of causative agents varies greatly between world regions and countries due to local food consumption and contamination. To prioritize public health interventions to reduce disease burden, national-level risk ranking evidence is needed. The overall aims of this project are to estimate the burden of disease (BoD) of selected chemical hazards in foods consumed in Denmark, and to identify the relative contribution of foods.MethodsWe identified chemicals on the basis of their presumed public health impact. The final list of chemicals was defined in agreement with the Danish Veterinary and Food Administration, and included: methylmercury, inorganic arsenic, cadmium, acrylamide, dioxin/dioxin-like PCBs and lead. We estimated BoD in terms of disability adjusted life years (DALY) in a model combining exposure assessment with dose response models to derive probabilities of health effects, taking an incidence-based approach. Data were collected from the Danish National Survey of Diet and Physical Activity, food monitoring, literature, and national statistics.ResultsWe estimated that methylmercury, inorganic arsenic, cadmium and acrylamide lead to a BoD of 514 DALY (95% uncertainty interval: 185, 990) in 2016 (preliminary results). Estimates for lead and dioxin/dioxin-like PCBs are pending. Methylmercury exposure from fish was the greatest contributor to overall burden (478 DALY), and acrylamide from potato products the second (30 DALY). The health outcomes leading to highest burden were intellectual disability and cancer.ConclusionsOur estimates will assist public health managers identifying the chemical contaminants in foods with the highest impact on public health in Denmark. Future research should focus on estimating the effect of mitigation strategies on the disease burden.

U2 - 10.1093/eurpub/ckz186.288

DO - 10.1093/eurpub/ckz186.288

M3 - Conference article

VL - 29

SP - 490

EP - 490

JO - European Journal of Public Health

JF - European Journal of Public Health

SN - 1101-1262

IS - Suppl. 4

ER -